Products Isotretinoin is commercially available in capsule and gel form (Roaccutane, generics). It has been approved in many countries since 1983 (United States: 1982, Accutane). This article refers to the capsules. See also under isotretinoin gel. Structure and properties Isotretinoin (C20H28O2, Mr = 300.4 g/mol) exists as a yellow to light orange crystalline powder that … Isotretinoin
Products Isotretinoin gel has been approved in many countries since 1994 (Roaccutan Gel, Germany: Isotrex Gel). Structure and properties Isotretinoin (C20H28O2, Mr = 300.4 g/mol) exists as a yellow to faint orange crystalline powder that is practically insoluble in water. Especially in solution, it is sensitive to air, heat, and light. Isotretinoin is a stereoisomer … Isotretinoin Gel
Products Tretinoin is commercially available as a cream and lotion (Airol) and in capsule form (Vesanoid). It has been approved in many countries since 1973. The Retin-A cream and gel went out of commerce in many countries at the end of 2012 for commercial reasons. This article refers to external treatment. Structure and properties Tretinoin … Tretinoin
Products Adapalene is commercially available as a cream and gel (Differin). It is also available in combination with benzoyl peroxide (Epiduo, Epiduo Forte). Adapalene has been approved in many countries since 1995. Structure and properties Adapalene (C28H28O3, Mr = 412.52 g/mol) is a synthetic derivative of naphthalic acid without the typical retinoid structure. It exists … Adapalene
Products Trifarotene was approved as a cream in the United States in 2019 and in Germany and many countries in 2020 (Aklief, Selgamis). Structure and properties Trifarotene (C29H33NO4, Mr = 459.6 g/mol) is a derivative of a terphenylic acid. It exists as a white to slightly yellow powder that is practically insoluble in water. Effects … Trifarotene
Products Tazarotene was approved in many countries in 1998 and is now no longer available. Zorac is out of commerce. External products are available in the United States (eg, Tazorac). Structure and properties Tazarotene (C21H21NO2S, Mr = 351.5 g/mol) is a prodrug that is rapidly biotransformed in the body to the active carboxylate metabolite tazarotenic … Tazarotene
Products Alitretinoin is commercially available in capsule form (Toctino) and was approved in many countries in 2009. Structure and properties Alitretinoin (C20H28O2, Mr = 300.4 g/mol) is a retinoid like the acne drugs isotretinoin (13- retinoic acid) or tretinoin (all-retinoic acid). Effects Alitretinoin (ATC D11AX19) has anti-inflammatory and immunomodulatory properties. Unlike other retinoids, it acts … Alitretinoin
Products Acitretin is commercially available in capsule form (Neotigason, Acicutuan). It has been approved in many countries since 1990. Structure and properties Acitretin (C21H26O3, Mr = 326.4 g/mol) is an aromatic derivative of retinoic acid (= tretinoin). It is lipophilic and exists as a greenish yellow powder that is practically insoluble in water. Effects Acitretin … Acitretin
Products Motretinide was commercially available as a cream in many countries and had been approved since 1981 (Tasmaderm). Unlike other topical retinoids such as isotretinoin (Roaccutane) or tretinoin (Retin-A), it was available without a physician’s prescription. It was discontinued in 2015. Structure and properties Motretinide (C23H31NO2, Mr = 353.5 g/mol) is an aromatic derivative of … Motretinide
