Products
Tazarotene was approved in many countries in 1998 and is now no longer available. Zorac is out of commerce. External products are available in the United States (eg, Tazorac).
Structure and properties
Tazarotene (C21H21NO2S, Mr = 351.5 g/mol) is a prodrug that is rapidly biotransformed in the body to the active carboxylate metabolite tazarotenic acid (AGN 190299). Tazarotene belongs to the acetylene retinoids.
Effects
Tazarotene (ATC D05AX05) affects cell formation, cell growth, differentiation, and has anti-inflammatory properties. The exact mechanism of action is not known. Tazarotene binds to the retinoic acid receptor (RAR) and modifies gene expression.
Indications
- Psoriasis (plaque psoriasis)
- Other areas of application (USA e.g. acne).
Dosage
According to the professional information. The drugs are applied thinly once a day locally as a gel or cream. The instructions in the package leaflet should be followed carefully.
Contraindications
Tazarotene should not be used in case of hypersensitivity, during pregnancy and lactation. It may have fertility-damaging properties. For complete precautions, see the drug label.
Interactions
Irritating or drying drugs should not be used concomitantly.
Adverse effects
The most common possible adverse effects include itching, burning, redness of the skin, and local irritation. Other common adverse effects include scaling, rash, contact dermatitis, skin pain, and worsening of psoriasis. Inflamed and dry skin have also been reported.
