Medical history (history of illness) is an important component in the diagnosis of endometrial cancer (cancer of the lining of the uterus). Family history Is there a history of frequent tumors in your family (colorectal or breast cancer)? Are there any hereditary diseases (HNPCC syndrome – Hereditary Non-Polyposis Colon Cancer Syndrome) in your family? Social … Uterine Cancer (Endometrial Carcinoma): Medical History
Neoplasms – Tumor Diseases (C00-D48). Other uterine tumors (uterine growths), benign or malignant – such as fibroids, leiomyomas, or uterine sarcoma. Genitourinary system (kidneys, urinary tract – sex organs) (N00-N99). Atypical adenomatous hyperplasia (precancerous; carcinoma risk circa 30%) – alteration of the endometrium that is considered a precursor of endometrial carcinoma.
The following are the most important diseases or complications that can be caused by endometrial carcinoma (cancer of the uterus): Neoplasms – Tumor Diseases (C00-D48). Metastasis Liver Lungs Lymph nodes Bones Overcontinuous growth into adjacent organs such as the vagina (sheath) or parametria (connective tissue structures of the pelvic cavity that extend from the wall … Uterine Cancer (Endometrial Carcinoma): Complications
Laboratory Diagnostics Ca 50 is elevated in circa 45% of cases (but does not matter clinically)Note: Ca 50 may also be elevated in: Ulcerative colitis, liver cirrhosis, pancreatitis, and gastric, colon, and pancreatic cancer. For the diagnosis of endometrial carcinoma, laboratory diagnostics play a role only in the context of histopathological and molecular diagnostic examination … Uterine Cancer (Endometrial Carcinoma): Test and Diagnosis
Mandatory medical device diagnostics. Transvaginal ultrasonography (ultrasound examination) – for basic diagnostics, in particular endometrial ultrasonography (ultrasound examination of the endometrium) [in postmenopausal women with uterine bleeding (bleeding from the uterus) applies to endometrial thickness (thickness of the endometrium) ≤ 3 mm: endometrial cancer must be excluded with a high degree of certainty (threshold of … Uterine Cancer (Endometrial Carcinoma): Diagnostic Tests
To prevent endometrial cancer (cancer of the lining of the uterus), attention must be paid to reducing individual risk factors. Behavioral risk factors Diet Foods containing acrylamide (Group 2A carcinogen) – this is metabolically activated to glycidamide, a genotoxic metabolite; an association between exposure to acrylamide and risk of endometrial carcinoma (Type I carcinoma) has … Uterine Cancer (Endometrial Carcinoma): Prevention
In many cases, endometrial cancer (cancer of the uterus) does not cause any symptoms and is therefore often discovered by chance. However, the following symptoms and complaints may indicate endometrial cancer: Leading symptoms Vaginal bleeding (bleeding from the vagina). Nine out of ten women with endometrial cancer had previous postmenopausal bleeding (postmenopausal bleeding; bleeding after … Uterine Cancer (Endometrial Carcinoma): Symptoms, Complaints, Signs
Pathogenesis (development of disease) Endometrial carcinoma is a malignant neoplasm (malignant neoplasm) of the epithelial portion of the endometrium (lining of the uterus). Two types are distinguished: Estrogen-associated type I carcinoma [estrogen and/or progesterone receptors: usually positive]. Estrogen-independent type II carcinoma [estrogen and/or progesterone receptors: mostly negative or weakly positive] Type I Estrogen-associated type I … Uterine Cancer (Endometrial Carcinoma): Causes
General measures Aim for or maintain normal weight!Determine BMI (body mass index, body mass index) or body composition using electrical impedance analysis BMI ≥ 25 → participation in a medically supervised weight loss program. Falling below the BMI lower limit (from the age of 45: 22; from the age of 55: 23; from the age … Uterine Cancer (Endometrial Carcinoma): Therapy
Histopathological classification of endometrial hyperplasia according to WHO 2014. New designation Synonyms Genetic modification Synchronous invasive EC (%) Progression to invasive carcinoma Hyperplasia without atypia Benign endometrial hyperplasia Simple, nonatypical endometrial hyperplasia. Complex, non-atypical endometrial hyperplasia Simple endometrial hyperplasia without atypia. Complex endometrial hyperplasia without atypia Low level of somatic mutations in scattered HE morphologically … Uterine Cancer (Endometrial Carcinoma): Classification
A comprehensive clinical examination is the basis for selecting further diagnostic steps: General physical examination – including blood pressure, pulse, body weight, height; further: Inspection (viewing). Skin and mucous membranes Abdominal wall and inguinal region (groin area). Gynecological examination Inspection Vulva (external, primary female sexual organs). Vagina (vaginal) [in rare cases, metastases/daughter tumors are possible … Uterine Cancer (Endometrial Carcinoma): Examination