Postthrombotic Syndrome: Causes

Pathogenesis (disease development)

Postthrombotic syndrome (PTS) is seen after approximately 10-15 years, in 40-60% of conventionally treated patients with deep vein thrombosis (TBVT). The result is chronic blood reflux in the veins due to vein wall damage and valvular insufficiency (valve leakage). This leads to decompensation (severe dysfunction) with edema formation (water retention), fibrosis (increased deposition of connective tissue), and localized peripheral cyanosis (purplish to bluish discoloration of the skin).

Etiology (Causes)

Biographic causes

  • Age* – increasing age

Behavioral causes

Disease-related causes

Cardiovascular system (I00-I99)

  • Pre-existing primary venous insufficiency* (venous weakness).
  • Deep vein thrombosis

Other causes

  • Inadequately performed anticoagulation (2-fold risk)* .

* Possible risk factors for the development of PTS that were present at the time of the onset of thrombosis.