Side effects of thyrostatic drugs

As with all drugs, side effects can be sorted by frequency. Not all preparations have an identical side effect profile. With the iodization inhibitors, the most common side effect is a slight allergic reaction of the skin, which subsides after a few days.

Occasionally, i.e. in less than one percent of those affected, the following side effects occur: Very rarely, nausea and vomiting are among the more frequent side effects of the iodination inhibitors. Drug fever is somewhat more frequent than with the iodination inhibitors. Any side effects that occur should always be discussed with the treating physician so that a dose adjustment or a change of medication can be made.

Agranulocytosis, i.e. changes in blood count which must be treated immediately,
Flavor disorders,
Drug fever and
Water retention.
Other blood picture changes, such as thrombocytopenia or pancytopenia,
The insulin autoimmune syndrome,
Polyneuropathies,
Vascular inflammation,
Inflammation of the liver,
Drug-induced lupus,
Kidney inflammation and
Joint inflammation.

The main indication for taking thyrostatic drugs is hyperthyroidism.With an overactive thyroid gland, those affected have an increased metabolic rate and a higher calorie requirement. Taking the thyrostatics should normalize the metabolic situation. However, since the affected persons have adapted their diet to the higher requirement, weight gain occurs initially. However, this can be limited again by normalizing the daily calorie intake.

Interactions

Thyrostatics have relatively few direct interactions with other drugs because they act very specifically on the thyroid gland. Increased or decreased amounts of iodine can influence the effect of thyrostatics and thus other drugs containing iodine can also have an effect on this. Secondarily, the effect of other drugs can be increased because the thyrostatics regulate the metabolism down and the drugs can be broken down more slowly.

In this case a dose adjustment of the other drugs is necessary. The thyrostatics are very specifically effective drugs, which have an effect on the iodine balance and the yodine level. This has no influence on the metabolism of the contraceptive pill.

However, since some thyrostatic drugs can cause nausea and vomiting, affected women should pay attention to additional contraception while side effects occur. Thyrostatics have relatively few interactions with other substances because they have a very specific effect on thyroid hormone production and iodine is only required there. Therefore there are no direct interactions with alcohol. Overall, however, thyrostatics can down-regulate the metabolism and thus also ensure that alcohol and other toxic substances are broken down more slowly than usual. The effect can therefore be increased.