Adenosine: Effects, Uses & Risks

Adenosine is a building block essential for the energy metabolism of the human body. Therapeutically, adenosine is used in particular to regulate cardiac arrhythmias and to lower blood pressure. What is adenosine? Therapeutically, adenosine is used in particular to regulate cardiac arrhythmias as well as to lower blood pressure. Adenosine is an endogenous nucleoside that … Adenosine: Effects, Uses & Risks

Antiarrhythmics

Indications For the treatment of cardiac arrhythmias. Active ingredients Class I (sodium channel blockers): class IA: Ajmaline (off-label). Quinidine (out of trade) Procainamide (out of commerce) Class IB: Lidocaine Phenytoin (not approved for this indication in many countries). Tocainide (not commercially available in many countries). Mexiletine (not on sale in many countries). Class IC: Encainid … Antiarrhythmics

Caffeine Withdrawal

Symptoms Possible symptoms of caffeine withdrawal in dependent individuals include: Headache Fatigue, drowsiness, weakness, low energy. Attention and concentration disorders, drowsiness. Dissatisfaction, disgruntlement Irritability Flu-like symptoms, muscle pain Changes in blood pressure, rapid heartbeat Nausea, vomiting, constipation. The discomfort may occur a few hours after caffeine abstinence and last a few to several days. Causes … Caffeine Withdrawal

Dipyridamole: Effects, Uses & Risks

Dipyridamole is the name given to an active substance from the group of platelet aggregation inhibitors. The drug is used primarily for the prophylaxis of strokes. What is dipyridamole? Dipyridamole is the name given to a drug belonging to the group of platelet aggregation inhibitors. The drug is used primarily for the prophylaxis of strokes. … Dipyridamole: Effects, Uses & Risks

Regadenoson

Products Regadenoson is commercially available as a solution for injection (Rapiscan). It was approved in the United States in 2008, in the EU in 2010, and in many countries in 2017. Structure and properties Regadenoson (C15H18N8O5, Mr = 390.4 g/mol) is present in the drug as a monohydrate. It is a derivative of adenosine. Effects … Regadenoson

Remdesivir

Products Remdesivir is commercially available as a powder for a concentrate for the preparation of an infusion solution (Veklury, Gilead Sciences Inc, USA). Provisional approval was granted in many countries and in the EU in July 2020. On November 25, 2020, the approval will be granted. In the U.S., the drug was registered in October. … Remdesivir

Adenosine

Products Adenosine is commercially available as a solution for injection (Krenosin). It has been approved in many countries since 1992. Structure and properties Adenosine (C10H13N5O4, Mr = 267.2 g/mol) exists as a white crystalline powder that is sparingly soluble in water at room temperature and more soluble in hot water. Effects Adenosine (ATC C01EB10) is … Adenosine

Adenine: Function & Diseases

Adenine is a heterobicyclic aromatic compound with a purine backbone that, as an organic nucleic base, forms one of the basic building blocks of genetic information in DNA and RNA along with three other bases. In addition, adenine in the form of a nucleoside or nucleotide plays an important role in metabolism as NAD, FADH2 … Adenine: Function & Diseases

Nucleosides: Function & Diseases

A nucleoside always consists of a nucleic base linked to the monosaccharide ribose or deoxyribose by an N-glycosidic bond. All 5 nucleic bases – the building blocks of DNA and RNA double and single helices – can be enzymatically converted into nucleosides. Some glycosides have physiological significance such as adenosine, which is the basic building … Nucleosides: Function & Diseases

Inosine: Function & Diseases

Inosine is a nucleoside of RNA belonging to the purine base group and is synthesized from the nucleic base adenine via the intermediate hypoxanthine. The rarely occurring inosine with attached D-ribose as a sugar molecule has special functions. As the only nucleic base, inosine has the possibility, in the phosphorylated form as a nucleotide, to … Inosine: Function & Diseases