Symptoms The possible initial symptoms of colon cancer include: Change in bowel habits, diarrhea or constipation. Bleeding, blood in the stool, black colored stool. Frequent urge to defecate, discharge of small and thin portions. Abdominal pain, flatulence, cramps. Weight loss, weakness, anemia Because the cancer grows slowly, it takes years before clinical symptoms finally appear. … Colon Cancer: Causes and Treatment
Products VEGF inhibitors are commercially available as injectables from various suppliers. The first agent in this group to be approved was pegaptanib (Macugen) in 2004, which is now off the market in many countries. Structure and properties The currently available VEGF inhibitors are therapeutic proteins (biologics). They are antibodies, antibody fragments, and fusion proteins. They … VEGF Inhibitors
Products Aflibercept is marketed as an injectable (Eylea). It was approved in many countries in 2012. Structure and properties Aflibercept (C4318H6788N1164O1304S32) is a recombinant fusion protein consisting of the extracellular portions of human VEGF receptor 1 and 2 coupled to the Fc receptor of human IgG1. Effects Aflibercept (ATC S01LA05) binds the growth factors VEGF-A … Aflibercept
