Products Cilazapril is commercially available in the form of film-coated tablets (Inhibace). Fixed combinations with hydrochlorothiazide are available (Inhibace plus). Cilazapril has been approved in many countries since 1990. Structure and properties Cilazapril (C22H31N3O5, Mr = 417.5 g/mol) exists as a white crystalline powder that is sparingly soluble in water. It is a prodrug that … Cilazapril
Products Telmisartan is commercially available in tablet form (Micardis, Micardis Plus + hydrochlorothiazide, generics). It has been approved in many countries since 1998. Generics entered the market in December 2013. In 2010, a fixed combination with amlodipine was registered (Micardis Amlo). Kinzal is no longer marketed in many countries. Structure and properties Telmisartan (C33H30N4O2, Mr … Telmisartan
Background That grapefruit juice can cause drug-drug interactions was discovered by chance in a clinical trial in 1989 and confirmed in an experiment by the same research group in 1991 (Bailey et al, 1989, 1991). This showed that simultaneous ingestion of grapefruit juice with the calcium channel blocker felodipine significantly increases the bioavailability of felodipine. … Interactions with Grapefruit Juice
Products Eprosartan is commercially available in the form of film-coated tablets (Teveten, generics). It has been approved in many countries since 1999 and is also used in fixed combination with hydrochlorothiazide (Teveten plus, generic). Structure and properties Eprosartan (C23H24N2O4S, Mr = 424.5 g/mol) is present in drugs as eprosartan mesilate, a white crystalline powder that … Eprosartan
Products Candesartan is commercially available in tablet form (Atacand, Blopress, generics). It is also combined fixed with hydrochlorothiazide (Atacand plus, Blopress plus, generics). Candesartan has been approved in many countries since 1997. In 2020, a fixed combination with amlodipine was also released. Structure and Properties Candesartan (C24H20N6O3, Mr = 440.45 g/mol) is administered in the … Candesartan
Products Losartan is commercially available in the form of film-coated tablets (Cosaar, generics). It has been approved in many countries since 1994 and was the first agent in the sartan group. Losartan is also combined with the diuretic hydrochlorothiazide (Cosaar Plus, generic). Structure and properties Losartan (C22H23ClN6O, Mr = 422.9 g/mol) is a biphenyl, imidazole, … Losartan
Products Irbesartan is commercially available in the form of film-coated tablets as a monopreparation (Aprovel, generic) and as a fixed combination with hydrochlorothiazide (Co-Aprovel). It has been approved in many countries since 1997. Generics entered the market in many countries in August 2012. Generic versions of the combination preprinted with hydrochlorothiazide went on sale in … Irbesartan
Products Amlodipine is commercially available in tablet form (Norvasc, generic). It has been approved in many countries since 1990. Amlodipine is also combined fixed with the following agents: Aliskiren, atorvastatin, perindopril, telmisartan, valsartan, olmesartan, hydrochlorothiazide, and indapamide. Structure and properties Amlodipine (C20H25ClN2O5, Mr = 408.9 g/mol) has a chiral center and is a racemate. It … Amlodipine (Norvasc)
Products Benazepril was commercially available as film-coated tablets (Cibacen, off label). It was also available as a fixed-dose combination with hydrochlorothiazide (Cibadrex, off label). Benazepril was approved in many countries beginning in 1990. Structure and properties Benazepril (C24H28N2O5, Mr = 424.5 g/mol) is present in drugs as benazepril hydrochloride, a white crystalline powder that is … Benazepril
Products Aliskiren is commercially available in the form of film-coated tablets (Rasilez, Rasilez HCT + hydrochlorothiazide). It was approved in many countries, in the EU and in the United States in 2007 (Other brand name: Tekturna). Note: Other combination preparations, e.g., with amlodpine (Rasilamlo), are no longer available. Structure and properties Aliskiren (C30H53N3O6, Mr = … Aliskiren
Aliskiren is a drug that acts as a renin inhibitor (renin inhibitor) for the treatment of arterial hypertension. It is sold under various trade names as a monotherapy as well as a combination preparation and is available by prescription. The drug was approved in the United States in March 2007, in Switzerland in June, and … Aliskiren: Effects, Uses & Risks
Products Ramipril is commercially available in tablet and capsule form (Triatec, generics). It has been approved in many countries since 1994 and is also available as a fixed combination with other agents. Structure and properties Ramipril (C23H32N2O5, Mr = 416.5 g/mol) exists as a white crystalline powder that is sparingly soluble in water. It is … Ramipril: Drug Effects, Side Effects, Dosage and Uses
