antiadiposita

Amphetamines

Products Amphetamines are commercially available as drugs in the form of tablets, sustained-release tablets, capsules, and sustained-release capsules. Structure and properties Amphetamines are derivatives of amphetamine. It is a methylphenethylamine structurally related to endogenous monoamines and stress hormones epinephrine and norepinephrine. Amphetamines are racemates and the –enantiomers. Effects Amphetamines have sympathomimetic, central stimulant, bronchodilator, psychoactive, … Amphetamines

Sibutramine

Products and withdrawal from the market Sibutramine was approved in 1999 and was commercially available in many countries in 10- and 15-mg capsule form (Reductil, Abbott AG). On March 29, 2010, Abbott AG, in consultation with Swissmedic, informed the public that the marketing authorization had been suspended. Since then, sibutramine may no longer be prescribed … Sibutramine

Amfepramone

Products Amfepramone is commercially available in the form of capsules (e.g., Regenon). The drug is not registered in many countries. Structure and properties Amfepramone (C 13 H 19 NO, M r = 205.3 g/mol) is structurally related to cathinone. Effects Amfepramone (ATC A08AA03) has indirect sympathomimetic, appetite suppressant, and antiadipose properties. The effects are due … Amfepramone

Antidiabetics

Active ingredients Insulins substitute for endogenous insulin: Human insulin Insulin analogues Biguanides reduce hepatic glucose formation: Metformin (Glucophage, generic). Sulfonylureas promote insulin secretion from beta cells: Glibenclamide (Daonil, generic). Glibornuride (Glutril, off label). Gliclazide (Diamicron, generic). Glimepiride (Amaryl, generics) Glinides promote insulin secretion from beta cells: Repaglinide (NovoNorm, generic). Nateglinide (Starlix) Glitazones decrease peripheral insulin … Antidiabetics

Hoodia Gordonii

Products In many countries, no medicinal products are registered with. Appropriate products can be ordered as dietary supplements over the Internet – but the quality is questionable. Stem plant Sweet ex Decne. of the dogbane family (subfamily Asclepiadoideae) is a slow-growing, environmentally resistant, succulent and thorny plant native to the Kalahari in South Africa and … Hoodia Gordonii

Fenfluramine

Products Finished medicines containing fenfluramine are no longer available in many countries. Ponflural is out of commerce. Fenfluramine has also been combined with phentermine (“fen-phen”). Structure and properties Fenfluramine (C12H16F3N, Mr = 231.3 g/mol) is a fluorinated amphetamine derivative and a racemate. The pure enantiomer dexfenfluramine has also been used medicinally. Effects Fenfluramine (ATC A08AA02) … Fenfluramine

Lorcaserin

Products Lorcaserin is commercially available in the form of film-coated tablets (Belviq). It was approved in the United States on June 27, 2012. It is not currently registered in many countries. Structure and properties Lorcaserin (C 11 H 14 ClN, M r = 195.7 g/mol) is present in drugs as lorcaserin hydrochloride and hemihydrate, a … Lorcaserin

Aminorex

Products Aminorex was approved in many countries in 1965 and withdrawn from the market in 1972 due to adverse effects (Menocil). Structure and properties Aminorex (C9H10N2O, Mr = 162.2 g/mol) is a dihydrooxazolamine structurally related to amphetamines. Effects Aminorex has appetite suppressant properties. The effects are due to the release of catecholamines. Indications For the … Aminorex

Dirlotapide

Products Dirlotapide is registered as an oral solution (Slentrol). It has been approved in many countries since 2008. Structure and properties Dirlotapide (C40H33F3N4O3, Mr = 674.7 g/mol) is an indole carboxamide and biphenyl derivative. It exists as a white crystalline powder that is soluble in water to <0.1 mg/ml. Effects Dirlotapide (ATCvet QA08AB91) is an … Dirlotapide

Phentermine

Products Phentermine is no longer available in many countries. It was formerly included in Adipex, Ionamine, and Normaform. Phentermine is still on sale in some countries, including the United States. Phentermine is also combined with topiramate (Qsymia) and fenfluramine (“fen-phen”). The combinations are controversial. The European Medicines Agency has rejected approval. Structure and properties Phentermine … Phentermine