How apomorphine works Apomorphine mimics the neurotransmitter dopamine in the central nervous system and binds to its docking sites (receptors). In this way, the active ingredient mediates the effects typical of dopamine. Parkinson’s disease: In Parkinson’s disease, nerve cells that produce and secrete dopamine gradually die. The use of apomorphine can therefore be helpful. However, … Apomorphine: Effect, Medical Applications, Side Effects
The area postrema is located at the rhomboid fossa in the brainstem and is part of the vomiting center. This functional unit of the nervous system elicits vomiting when appropriately stimulated, thereby performing a protective role. Antiemetics inhibit this response as part of the treatment of traumatic brain injury and other neurologic conditions. What is … Area Postrema: Structure, Function & Diseases
Symptoms Erectile dysfunction or so-called erectile dysfunction refers to the persistent or recurrent inability to achieve or maintain an erection, which is necessary for sexual activity. This makes sexual intercourse impossible and severely limits sexual life. For the affected man, erectile dysfunction can be a great psychological burden. It can trigger stress, negatively affect self-esteem … Erectile Dysfunction: Causes and Treatment
Products Quinagolide is commercially available in tablet form (Norprolac). It has been approved in many countries since 1994. Structure and properties Quinagolide (C20H33N3O3S, Mr = 395.56 g/mol) is a non-ergoline dopamine agonist with a similar structure to apomorphine. It is present in drugs as quinagolide hydrochloride. Effects Quinagolide (ATC G02CB04) has dopaminergic properties and inhibits … Quinagolide
Ondansetron is a major antiemetic that belongs to the setrone class of drugs. Ondansetron achieves its effects by causing inhibition of 5HT3 receptors. Because of this mode of action, ondansetron is also considered a serotonin receptor antagonist. The drug is marketed under the trade name Zofran and is used to treat nausea, vomiting, and emesis. … Ondansetron: Effects, Uses & Risks
Products Ondansetron is commercially available in the form of film-coated tablets, meltable tablets (lingual tablets), as a syrup, and as an infusion/injection preparation. In addition to the original Zofran, generic versions are also available. Ondansetron was introduced in 1991 as the first active ingredient from the group of 5-HT3 receptor antagonists was approved. Structure and … Ondansetron
Effects Aphrodisiac Medical indications To promote sex drive or potency. Erectile dysfunction in men “Hypoactive Sexual Desire Disorder” (decreased sexual drive). Active ingredients Use v.a. in erectile dysfunction: phosphodiesterase-5 inhibitors increase blood flow to the corpus cavernosum of the penis and act only during sexual stimulation: Sildenafil (Viagra) Tadalafil (Cialis) Vardenafil (Levitra) Prostaglandins must be … Aphrodisiacs
Apomorphine‘s similarity to dopamine, a neurotransmitter produced naturally in the body, makes it one of the most effective dopamine mimics available to medicine and pharmacy today. Formerly used primarily as an emetic, apomorphine now serves a broader range of actions in a variety of indication settings. What is apomorphine? The agent receives its most common … Apomorphine: Effects, Uses & Risks
Effects The majority of antiparkinsonian drugs are directly or indirectly dopaminergic. Some are anticholinergic in action. Indications Parkinson’s disease, including drug-induced Parkinson’s disease in some cases. Drug treatment Overview of drug therapy: 1. dopaminergic agents Levodopa is a precursor of dopamine and is considered the most important and effective pharmacotherapy for PD. Combining it with … Antiparkinsonian
Products Uprima sublingual tablets (2 mg, 3 mg) for erectile dysfunction are no longer marketed in many countries. The marketing authorization was not renewed by Abbott AG in 2006. Commercial reasons were cited, probably attributed to competition from phosphodiesterase-5 inhibitors (e.g., sildenafil, Viagra). It is also possible that a post-marketing study had played a role, … Apomorphine
Effects emetic: induce vomiting Active ingredients Dopamine agonists: Apomorphine Herbal emetics: Emetic root: ipecacuanha, emetine and corresponding preparations. Other: Copper sulfate (obsolete) Sodium chloride Xylazine in veterinary medicine
Products Dopamine agonists are commercially available in the form of tablets, sustained-release tablets, transdermal patches, and injectables, among others. Structure and properties The first active ingredients, such as bromocriptine (Figure), were derived from ergot alkaloids. These are referred to as ergoline dopamine agonists. Later, agents with a nonergoline structure, such as pramipexole, were also developed. … Dopamine Agonists
