How Argatroban works Argatroban interferes with blood clotting by inhibiting the enzyme involved, thrombin – the active ingredient is therefore a direct thrombin inhibitor. Thrombin is normally activated by enzymes that have themselves been activated by vascular damage or foreign bodies in the bloodstream. It then converts fibrinogen at the affected site to fibrin – … Argatroban: Effects, Uses, Side Effects
Argatroban belongs to the group of active substances known as anticoagulants and is used to inhibit blood clotting. The drug has been sold in Germany since 2005 under the name Argatra Multidose and is administered as an infusion solution. What is Argatroban? Argatroban belongs to the anticoagulant group of drugs and is used to inhibit … Argatroban: Effects, Uses & Risks
Effects Antithrombotic Anticoagulant Fibrinolytic Active ingredients Salicylates: Acetylsalicylic acid 100 mg (Aspirin Cardio). P2Y12 antagonists: Clopidogrel (Plavix, generics). Prasugrel (Efient) Ticagrelor (Brilique) GP IIb/IIIa antagonists: Abciximab (ReoPro) Eptifibatide (Integrilin) Tirofiban (Aggrastat) PAR-1 antagonists: Vorapaxar (Zontivity) Vitamin K antagonists (coumarins): Phenprocoumon (Marcoumar). Acenocoumarol (Sintrom) Not on sale in many countries: dicoumarol, warfarin. Heparins: Heparin sodium Heparin-Calcium … Antithrombotics
Products Thrombin inhibitors are commercially available in many countries in the form of infusion preparations and as capsules. The first oral thrombin inhibitor to be launched was ximelagatran (Exanta) in 2003. Due to its liver toxicity, sales had to be discontinued. Currently, the most widely used oral and direct thrombin inhibitor, dabigatran (Pradaxa), was approved … Thrombin Inhibitors
Products Argatroban is commercially available as a concentrate for the preparation of an infusion solution (Argatra). It was approved in many countries in 2014. Structure and properties Argatroban (C23H36N6O5S, Mr = 508.6 g/mol) is a derivative of the amino acid arginine. Effects Argatroban (ATC B01AE03) has antithrombotic properties. It inhibits fibrin formation, coagulation factor activation, … Argatroban
Heparin-induced thrombocytopenia is a condition that can occur after the administration of heparin. In this condition, the number of platelets in the blood drops below 50 percent of normal. What is heparin-induced thrombocytopenia? Heparin-induced thrombocytopenia (HIT) is a complication of treatment with heparin. Heparin is a standard medical drug used for anticoagulation (inhibition of blood … Heparin-induced Thrombocytopenia: Causes, Symptoms & Treatment
