Elimination at the kidney The kidneys, along with the liver, play a central role in the elimination of pharmaceutical agents. They can be filtered at the glomerulus of the nephron, actively secreted at the proximal tubule, and reabsorbed at various tubular segments. In renal insufficiency, these processes are impaired. This may result in a renally … Dose Adjustment in Renal Insufficiency
Symptoms Condylomata acuminata is a benign infectious disease of the skin and mucous membranes caused by human papillomavirus. It manifests itself in benign warts, called genital warts, which appear in the genital and/or anal areas. However, such warts appear in less than 1% of people infected with HPV. In men, the tip of the penis … Condylomata Acuminata
Products Cidofovir was initially marketed in many countries as an infusion concentrate under the brand name Vistide (Gilead). It was approved in many countries in 1997 and had not been available since 2014. In 2017, a concentrate for the preparation of an infusion solution was approved (Sidovis). Structure and properties Cidofovir (C8H14N3O6P, Mr = 279.2 … Cidofovir
Symptoms Dell’s warts are a viral and benign infectious disease of the skin or mucosa that occurs primarily in children and immunocompromised individuals. The disease manifests as single or numerous round, dome-shaped, shiny, skin-colored or white papules that usually have a central depression with a spongy core that can be squeezed. A single patient may … Molluscum Contagiosum (Dell Warts)
What are prodrugs? Not all active pharmaceutical ingredients are directly active. Some must first be converted to the active substance by an enzymatic or non-enzymatic conversion step in the body. These are the so-called . The term was introduced by Adrien Albert in 1958. It is estimated that up to 10% of all active ingredients … Prodrugs
Products Probenecid is commercially available in tablet form (Santuril). Santuril has been approved in many countries since 2005. Structure and properties Probenecid (C13H19NO4S, Mr = 285.4 g/mol) is a white crystalline powder that is practically insoluble in water. Effects Probenecid (ATC M04AB01) inhibits tubular reabsorption of uric acid and secretion of organic anions. It thus … Probenecid
Symptoms Three-day fever is most common in infants 6-12 months of age and in young children. Newborns are still protected thanks to maternal antibodies. After an incubation period of 5-15 days, the disease begins with sudden onset and high fever that lasts for 3-5 days. Febrile convulsions are a known and comparatively frequent complication (about … Three Day Fever
