Products Imatinib is commercially available in the form of film-coated tablets (Gleevec, Gleevec GIST, generic). It has been approved in many countries since 2001. Generics came on the market in 2016. They were not approved for the treatment of gastrointestinal stromal tumors (GIST) because this indication was still protected by a patent. In 2017, imatinib … Imatinib
Products Alprazolam is commercially available as tablets, sustained-release tablets, and sublingual tablets (Xanax, generics). It has been approved in many countries since 1980. “Xanax” is a palindrome and remains the same when read forwards or backwards. Structure and properties Alprazolam (C17H13ClN4, Mr = 308.7 g/mol) exists as a white crystalline powder that is practically insoluble … Alprazolam
Products Flibanserin (Addyi) was approved in the United States in 2015 in the form of film-coated tablets. The drug has not yet been registered in many countries. Flibanserin was originally developed at Boehringer Ingelheim as an antidepressant. It was marketed in the United States by Sprout Pharmaceuticals. Structure and properties Flibanserin (C20H21F3N4O, Mr = 390.4 … Flibanserin
Products Artemether is commercially available as tablets and dispersible tablets as a fixed combination with lumefantrine (Riamet, some countries: Coartem). It has been approved in many countries since 1999. Structure and properties Artemether (C16H26O5, Mr = 298.4 g/mol) is a methyl ether dervate of the sesquiterpene artemisinin from the annual mugwort (, Qing Hao), a … Artemether
Products The selective serotonin reuptake inhibitors (SSRIs) are mainly taken in the form of film-coated tablets or capsules. In addition, other dosage forms such as dispersible tablets, melting tablets and drops are available. Zimelidin was the first to be developed in the 1970s and was approved in the early 1980s. Sales had to be discontinued … Selective Serotonin Reuptake Inhibitor
Products Avanafil is commercially available in tablet form (Spedra, some countries: Stendra). It was approved in the US in April 2012, in the EU in 2013, and in many countries in 2016. Structure and properties Avanafil (C23H26ClN7O3, Mr = 483.95 g/mol) is a pyrimidine derivative. It exists as a white crystalline powder that is practically … Avanafil
P-glycoprotein P-glycoprotein (P-gp, MDR1) is a primary active efflux transporter with a molecular weight of 170 kDa, belonging to the ABC superfamily and consisting of 1280 amino acids. P-gp is the product of the -gene (formerly: ). P is for , ABC is for . Occurrence P-glycoprotein is found on various tissues of the human … P-Glycoprotein
Effects P2Y12 antagonists are antiplatelet agents and prevent the formation of blood clots. The effects are due to binding to the adenosine diphosphate receptor P2Y12 on platelets. This receptor plays a central role in glycoprotein (GP)-IIb/IIa activation and platelet aggregation. The continuous binding of adenosine diphosphate (ADP) to P2Y12 is an important prerequisite for thrombus … P2Y12 Antagonists
Products Budesonide is commercially available as a monopreparation for inhalation as a powder inhaler and suspension (Pulmicort, generics). It is also combined fixed with formoterol (Symbicort Turbuhaler, Vannair Dosage Aerosol). This article refers to monotherapy. Budesonide has been approved in many countries since 1988. Structure and properties Budesonide (C25H34O6, Mr = 430.5 g/mol) is a … Budesonide (Inhalation)
Products Budesonide nasal sprays have been approved in many countries since 1995 (Cortinasal, generic). Rhinocort nasal spray has not been marketed since 2018. Sales of the Rhinocort turbuhaler were discontinued in 2020. Structure and properties Budesonide (C25H34O6, Mr = 430.5 g/mol) is a racemate and exists as a white, crystalline, odorless, tasteless powder that is … Budesonide Nasal Spray
Products Budesonide sustained-release capsules have been approved in many countries since 1998 (Entocort CIR, Budenofalk). Structure and properties Budesonide (C25H34O6, Mr = 430.5 g/mol) is a racemate and exists as a white, crystalline, odorless, tasteless powder that is practically insoluble in water. Effects Budesonide (ATC R03BA02) has anti-inflammatory, antiallergic, and immunosuppressive properties. The effects are … Budesonide Capsules
