Products Brentuximab vedotin is commercially available as a powder for the preparation of an infusion solution (Adcetris). It has been approved in many countries since 2013. Structure and properties Brentuximab vedotin is an anti-CD30 antibody-drug conjugate, a recombinant chimeric lgG1 antibody conjugated to the cytotoxic agent monomethylauristatin E (MMAE, C39H67N5O7, Mr = 718.0 g/mol). It … Brentuximab Vedotin
Products Gemtuzumab ozogamicin is approved as a powder for a concentrate for the preparation of an infusion solution (Mylotarg). It was approved in the United States in 2017, in the EU in 2018, and in many countries in 2019 It was previously marketed in the United States between 2000 and 2010 but was withdrawn from … Gemtuzumab Ozogamicin
Products Pralatrexate is commercially available as an infusion solution (Folotyn). It has been approved in many countries since 2013. Structure and properties Pralatrexate (C23H23N7O5, Mr = 477.5 g/mol) is a folic acid analog and exists as a racemate. It is a white to yellow substance that is soluble in water. Effects Pralatrexate (ATC L01BA05) has … Pralatrexate
Products Ifosfamide is commercially available as a dry substance for intravenous infusion (Holoxan). It has been approved in many countries since 1979. Structure and properties Ifosfamide (C7H15Cl2N2O2P, Mr = 261.1 g/mol) is an oxazaphosphorine and nitrogen-lost derivative, and an analog of cyclophosphamide. Ifosfamide is a racemate and exists as a white, crystalline, hygroscopic powder that … Ifosfamide
Products Avelumab was approved in the United States, the EU, and many countries in 2017 as a concentrate for the preparation of an infusion solution (Bavencio). Structure and properties Avelumab is a human IgG1λ monoclonal antibody against programmed cell death ligand 1 (PD-L1) with a molecular weight of 147 kDa. It is produced by biotechnological … Avelumab
Products Cladribine was approved for the treatment of multiple sclerosis in the EU in 2017 and in the United States and many countries in 2019 in tablet form (Mavenclad). Cladribine has also been commercially available as an infusion and injection solution in many countries since 1998 (Litak). This article relates to MS therapy. Structure and … Cladribine
