Products Azacitidine is commercially available as a lyophilizate for the preparation of a suspension for injection (Vidaza, generic). It has been approved in many countries since 2006. Structure and properties Azacitidine (C8H12N4O5, Mr = 244.2 g/mol) is a derivative of the nucleoside cytidine found in nucleic acids. It belongs to the pyrimidine nucleoside analogues. Azacitidine … Azacitidine
Products Mitomycin is commercially available as a powder for the preparation of a solution for injection or infusion (Mitem). Structure and properties Mitomycin (C15H18N4O5, Mr = 334.3 g/mol) exists as a blue-violet crystalline powder or as crystals and is sparingly soluble in water. It is formed by a strain of. Mitomycin was first isolated in … Mitomycin
Products Mitotane is commercially available in tablet form (Lysodren). It was approved in many countries in 2010. Structure and properties Mitotane or 1-chloro-2-(2,2-dichloro-1-(4-chlorophenyl)ethyl)benzene (C14H10Cl4, Mr = 320.041 g/mol) is a derivative of an insecticide. Effects Mitotane (ATC L01XX23) has a cytotoxic effect on the adrenal glands and may also cause adrenal inhibition without cell destruction. … Mitotan
Products Ingenol mebutate was commercially available as a gel (Picato). It was approved in many countries in 2013, and in the EU and the U.S. as early as 2012. In 2020, approval was withdrawn because an increased risk of skin cancer was observed with the treatment. Structure and properties Ingenol mebutate (C25H34O6, Mr = 430.5 … Ingenol Mebutate
Products Obinutuzumab is commercially available as a concentrate for the preparation of an infusion solution (Gazyvaro). It has been approved in many countries since 2014. Structure and properties Obinutuzumab is a recombinant, monoclonal, and humanized type II antibody against CD20 of the IgG1 isotype. It has a molecular weight of approximately 150 kDa. Obinutuzumab is … Obinutuzumab
Products Ocrelizumab was approved in many countries and in the United States in 2017 and in the EU in 2018 as an infusion concentrate (Ocrevus). Structure and properties Ocrelizumab is a humanized IgG1 monoclonal antibody with a molecular mass of 145 kDa. It is produced by biotechnological methods. Ocrelizumab is the successor agent to rituximab … Ocrelizumab
Products Carmustine is commercially available in many countries as a powder and solvent for the preparation of an infusion solution (BiCNU). An implant is also available in some countries (Gliadel). Structure and properties Carmustine (C5H9Cl2N3O2, Mr = 214.0 g/mol) belongs to the nitrosoureas. It exists as a yellowish, granular powder that is very sparingly soluble … Carmustine
Products Cyclophosphamide is commercially available in the form of dragées and as a dry substance for intravenous infusion (Endoxan). It has been approved in many countries since 1960. Structure and properties Cyclophosphamide (C7H15Cl2N2O2P, Mr = 261.1 g/mol) is a cytostatic drug belonging to the group of oxazaphosphorines, nitrogen-lost derivative. Effects Cyclophosphamide (ATC L01AA01) has cytotoxic … Cyclophosphamide
Definition Plant antraceene derivatives with the common structural feature 1,8-dihydroxyanthrone. Numerous derivatives (anthrones, anthranols, anthraquinones, dianthrones, naphthodianthrones). 1,8-Dihydroxyanthrone: Effects Laxative (Prodrugs) Antidepressant: St. John’s wort Antiarthrotic: Rhine, Diacerein (Verbonil). Cytotoxic: mitoxantrone (Novantrone). Indications Primarily for short-term treatment of constipation. Bowel emptying Some: Osteoarthritis Medicinal drugs Aloe: e.g. aloin A American rotten tree (Cascara bark) Sloth … Anthranoid
Mushroom The green tuberous-leaf mushroom of the Amanitaceae family is native to Europe and grows under oaks, beeches, sweet chestnuts and other deciduous trees. It is also found on other continents. The fruiting body is white and the cap has a greenish color. The less poisonous fly agaric also belongs to the same family. Ingredients … Green Amanita Mushroom
Products Olaparib was approved in the United States and EU in 2014 and in many countries in 2015 in capsule form (Lynparza). Later, film-coated tablets were also registered. Structure and properties Olaparib (C24H23FN4O3, Mr = 434.5 g/mol) Effects Olaparib (ATC L01XX46) has antitumor and cytotoxic properties. The effects are due to inhibition of PARP (poly-(ADP-ribose) … Olaparib
Products Inotuzumab ozogamicin was approved in many countries, in the EU, and in the United States in 2017 as a powder for a concentrate for the preparation of an infusion solution (Besponsa). See also under gemtuzumab ozogamicin. Structure and properties Inotuzumab ozogamicin is an antibody-drug conjugate directed against CD22. Inotuzumab is a humanized lgG4 monoclonal … Inotuzumab Ozogamicin
