Products No drugs containing dihydroartemisinin are currently approved in many countries. However, the prodrug artemether (Riamet, with lumefantrine), which is metabolized in the body to dihydroartemisinin, is available. It is also combined fixed with piperaquine; see Piperaquine and Dihydroartemisinin. Structure and properties Dihydroartemisinin (C15H24O5, Mr = 284.3 g/mol) is derived from artemisinin from annual mugwort … Dihydroartemisinin
Symptoms Malaria (Italian, “bad air”) manifests itself in the following symptoms, which usually appear a few weeks after transmission. The incubation period ranges from a few days to several years: High fever, sometimes with rhythmic attacks of fever, every second or third day. However, the fever may also occur irregularly. Chills, profuse sweating. Headache, muscle … Malaria Causes and Treatment
Effects Antiparasitic against plasmodia. Indications Malaria Malaria prophylaxis Also for the treatment of rheumatic diseases, lupus erythematosus. Off-label: some antimalarials such as quinine and chloroquine are used off-label to treat calf cramps. Active ingredients Aminoquinolines: Amodiaquine Chloroquine (Nivaquine, out of commerce). Hydroxychloroquine (Plaquenil) Mepacrine Pamaquin Piperaquine Primaquine Tafenoquin (crinoline) Biguanides: Proguanil (Malarone + Atovaquone). Cycloguanilembonate … Antimalarials
Products Artemether is commercially available as tablets and dispersible tablets as a fixed combination with lumefantrine (Riamet, some countries: Coartem). It has been approved in many countries since 1999. Structure and properties Artemether (C16H26O5, Mr = 298.4 g/mol) is a methyl ether dervate of the sesquiterpene artemisinin from the annual mugwort (, Qing Hao), a … Artemether
Products No drugs containing artesunate are currently approved in many countries. Structure and properties Artesunate (C19H28O8, Mr = 384.4 g/mol) is a succinyl derivative and a prodrug of dihydroartemisinin. It is derived from artemisinin from annual mugwort (, qing hao), a medicinal plant used in traditional Chinese medicine. Effects Artesunate (ATC P01BE03) has antiparasitic properties … Artesunate
