Products Dihydroergocriptine is no longer registered in many countries. Cripar is out of commerce. Effects Dihydroergocriptine (ATC N04BC03) is dopaminergic and acts selectively on D2 receptors. It has no activity on serotoninergic or adrenergic receptors. Indications Parkinson’s disease Early stages of Parkinson’s disease, as monotherapy or in combination with an L-dopa preparation. Interval treatment of … Dihydroergocriptine
Products Dopamine agonists are commercially available in the form of tablets, sustained-release tablets, transdermal patches, and injectables, among others. Structure and properties The first active ingredients, such as bromocriptine (Figure), were derived from ergot alkaloids. These are referred to as ergoline dopamine agonists. Later, agents with a nonergoline structure, such as pramipexole, were also developed. … Dopamine Agonists
Structure and properties Depending on the side chains, ergot alkaloids are classified into two different groups: Ergometrine-type ergot alkaloids (e.g., ergometrine, methylergometrine). Peptide-type ergot alkaloids (e.g., ergotamine, ergotoxine, bromocriptine). Effects Ergot alkaloids exhibit the following effects in varying degrees: Partial agonists at alpha-adrenoreceptors. Partial agonists at serotonin receptors Stimulation of dopamine receptors Contraction of vascular … Ergot Alkaloids
