elvitegravir

Elvitegravir

Products Elvitegravir is commercially available as film-coated tablets in fixed combination with other antiretroviral agents and cobicistat (Stribild, successor: Genvoya). It has been approved in many countries since 2013. Stribild: elvitegravir, cobicistat, emtricitabine, and tenofovirdisoproxil. Genvoya: elvitegravir, cobicistat, emtricitabine and tenofoviralafenamide. Structure and properties Elvitegravir (C23H23ClFNO5, Mr = 447.9 g/mol) is a dihydroquinolone derivative. It … Elvitegravir

Cobicistat

Products Cobicistat is commercially available as a monopreparation (Tybost) and as a fixed combination with elvitegravir, emtricitabine, and tenofovirdisoproxil in the form of film-coated tablets (Stribild). It has been approved in many countries since 2013. Other combination products exist with darunavir (Rezolsta) and with atazanavir (Evotaz). Structure and properties Cobicistat (C40H53N7O5S2, Mr = 776.0 g/mol) … Cobicistat

Integrase Inhibitors

Effects Integrase inhibitors have antiviral against HIV viruses. They inhibit the catalytic activity of HIV integrase, which is an HIV-encoded enzyme required for viral replication. Integrase inhibition prevents integration of the HIV genome into the host cell genome during the early phase of infection. Indications For the treatment of infection with the HIV virus (HIV). … Integrase Inhibitors

Tenofoviralafenamide

Products Various drugs containing tenofoviralafenamide are on the market worldwide. In many countries, tenofoviralafenamide was first approved in 2016 (United States: 2015). Biktarvy: bictegravir, emtricitabine, and tenofoviralafenamide (HIV). Genvoya: elvitegravir, cobicistat, emtricitabine, and tenofoviralafenamide (HIV). Descovy: emtricitabine and tenofoviralafenamide (HIV). Odefsey: emtricitabine, rilpivirine and tenofoviralafenamide (HIV). Symtuza: darunavir + cobicistat + emtricitabine + tenofoviralafenamide. Vemlidy: … Tenofoviralafenamide

Elvitegravir: Effects, Uses & Risks

Elvitegravir is a drug that belongs to the active substances of integrase inhibitors. In human medicine, elvitegravir is used primarily as a drug for the treatment of infections with the HIV-1 virus. Physicians always use the active ingredient together with other drugs that have an antiretroviral effect. Doctors particularly often combine elvitegravir with the substance … Elvitegravir: Effects, Uses & Risks