Interferons: Function & Diseases

Interferons are tissue hormones composed of relatively short-chain polypeptides, proteins, or glycoproteins. Together with interleukins and other groups of substances, they belong to the cytokines that initiate and control the immune responses of the immune system. Interferons are produced mainly by cells of the immune system, but also by fibroblasts, and primarily control antiviral and … Interferons: Function & Diseases

Follitropin Alfa

Products Follitropin alfa is commercially available as an injectable. It has been approved in many countries since 1995. Biosimilars are approved in some countries (Switzerland: Ovaleap, 2018). Structure and properties Follitropin alfa is a follicle-stimulating hormone (FSH) produced by biotechnological methods. It is a heterodimer and consists of two distinct glycoproteins, the α-subunit (92 amino … Follitropin Alfa

Follitropin Beta

Products Follitropin beta is commercially available as a solution for injection (Puregon). It has been approved in many countries since 2001. Structure and properties Follitropin beta is a recombinant human follicle-stimulating hormone (FSH) produced by biotechnological methods. The amino acid sequence corresponds to human FSH. It differs from follitropin alfa in glycosylation. FSH is a … Follitropin Beta

Monoclonal Antibodies

Products The first therapeutic monoclonal antibody was approved in 1986. Muromonab-CD3 (Orthoclone OKT3) binds to the CD3 receptor on T cells and has been used in transplantation medicine. Numerous drugs containing antibodies are now available. A selection of active substances can be found at the end of this article. These are expensive drugs. For example, … Monoclonal Antibodies

Glycoproteins: Function & Diseases

About half of all proteins in the human body are glycoproteins. The substances play a role as cell components as well as immune substances. They are formed primarily as part of what is known as N-glycosylation and can cause serious diseases if incorrectly assembled. What are glycoproteins? Glycoproteins are proteins with tree-like branched heteroglycan residues. … Glycoproteins: Function & Diseases

Urofollitropin

Products Urofollitropin is commercially available as an injectable (fostimone). It has been approved in many countries since 1996. Structure and properties Urofollitropin is a highly purified human follicle-stimulating hormone (FSH) derived from the urine of postmenopausal women. FSH is a heterodimer and consists of two distinct glycoproteins, the α-subunit (92 amino acids) and the β-subunit … Urofollitropin

Epithelial-mesenchymal Transition: Function, Role & Diseases

Epithelial-mesenchymal transition, or EMT, refers to the transformation of epithelial cells into mesenchymal cells. This transformation possesses great importance in embryonic development. However, this process also plays a key role in the development of metastases in carcinomas. What is epithelial-mesenchymal transition? Epithelial-mesenchymal transition is a conversion of already differentiated epithelial cells into undifferentiated mesenchymal stem … Epithelial-mesenchymal Transition: Function, Role & Diseases