Carboplatin

Products Carboplatin is commercially available as an infusion solution (paraplatin, generic). It has been approved in many countries since 1986. Structure and properties Carboplatin (C6H12N2O4Pt, Mr = 371.3 g/mol) is a platinum compound. It exists as a colorless crystalline powder that is sparingly soluble in water. Carboplatin is structurally related to cisplatin, the first platinum … Carboplatin

Iron Deficiency Causes and Treatment

Background The iron content of an adult is about 3 to 4 g. In women, the value is somewhat lower than in men. About two-thirds is bound to heme as so-called functional iron, is present in hemoglobin, myoglobin, and in enzymes, and is essential for oxygen supply and metabolism. One-third is found in the iron … Iron Deficiency Causes and Treatment

Progeria Type 1 (Hutchinson-Gilford Progeria Syndrome): Causes, Symptoms & Treatment

Progeria type 1, also known as Hutchinson-Gilford progeria syndrome, is a first-ever, albeit extremely rare, childhood disease. In very general terms, progeria can be described as a disease that causes the affected child to age at a rapid rate. What is progeria type 1? The name of the disease called progeria type 1 is derived … Progeria Type 1 (Hutchinson-Gilford Progeria Syndrome): Causes, Symptoms & Treatment

Hair Loss: Hair Transplants

If the hair is slowly thinning, bald patches can be made to disappear by hair transplantation. Nevertheless, one should be aware that with a hair transplant one cannot restore the hair splendor of youth. A pronounced baldness surrounded by a smaller crown of hair can never be covered again with the hair density of an … Hair Loss: Hair Transplants

Medical Liability

Medical liability: what happens if there is a treatment error? Mistakes can always happen – even in medicine. However, a doctor naturally works with the greatest possible care, but what to do if a treatment error occurs? Is there medical liability? Jurisprudence has formed case groups for this purpose. In this guide, we explain what … Medical Liability

Gefitinib

Products Gefitinib is commercially available in the form of film-coated tablets (Iressa). It was approved in many countries in 2011. Structure Gefitinib (C22H24ClFN4O3, Mr = 446.9 g/mol) is a morpholine and aniline quinazoline derivative. It exists as a white powder that is sparingly soluble in water, especially at high pH. Effects Gefitinib (ATC L01XE02) is … Gefitinib

Alfatradiol

Products In many countries, no finished medicinal products containing alfatradiol are commercially available. In Germany, preparations for external use are available (e.g., Ell-Cranell). Structure and properties Alfatradiol (C18H24O2, Mr = 272.4 g/mol) or 17α-estradiol is a stereoisomer of the female sex hormone 17β-estradiol. Effects Alfatradiol inhibits the enzyme 5α-reductase, thereby inhibiting the synthesis of the … Alfatradiol

Gemcitabine

Products Gemcitabine is commercially available as a lyophilizate for the preparation of an infusion solution (Gemzar, generics). It has been approved in many countries since 1997. Structure and properties Gemcitabine (C9H11F2N3O4, Mr = 263.2 g/mol) is present in drugs as gemcitabine hydrochloride, a white substance that is soluble in water. The pyrimidine gemcitabine is a … Gemcitabine

Captopril Effects and Side Effects

Products Captopril was approved in many countries in 1980 as the first active ingredient in the ACE inhibitor group. The original Lopirin is now off the market. Generic products are available in tablet form. Structure and properties Captopril (C9H15NO3S, Mr = 217.3 g/mol) is a derivative of the amino acid proline. It exists as a … Captopril Effects and Side Effects

Finasteride

Products Finasteride is commercially available as film-coated tablets (prostate: Proscar, generic, 5 mg; hair loss: Propecia, generic, 1 mg). It has been approved in many countries since 1993. Propecia was launched five years later, in 1998. Structure and properties Finasteride (C23H36N2O2, Mr = 372.5 g/mol) is a 4-azasteroid and structurally related to testosterone. It exists … Finasteride