Products GnRH analogs are commercially available in many countries in the form of injectables, implants, and nasal sprays, among others. The first agent to be approved was goserelin (Zoladex) in 1990. Structure and properties GnRH analogs are synthetically produced derivatives of gonadotropin-releasing hormone (GnRH, LHRH) produced in the hypothalamus. GnRH is a decapeptide and has … GnRH Analogs
Products Histrelin is commercially available as an implant (Vantas). It was approved in many countries in 2010. Structure and properties Histrelin is present in drugs as histrelin acetate. The nonapeptide is a synthetic analog of the natural gonadotropin-releasing hormone GnRH. Histrelin: 5-oxo-Pro-His-Trp-Ser-Tyr-Ntbenzyl-D-His-Leu-Arg-N-ethyl-L-prolinamide. GnRH: Pyr-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly Effects Histrelin (ATC H01CA03) blocks the release of LH and FSH … Histrelin
