Elvitegravir

Products Elvitegravir is commercially available as film-coated tablets in fixed combination with other antiretroviral agents and cobicistat (Stribild, successor: Genvoya). It has been approved in many countries since 2013. Stribild: elvitegravir, cobicistat, emtricitabine, and tenofovirdisoproxil. Genvoya: elvitegravir, cobicistat, emtricitabine and tenofoviralafenamide. Structure and properties Elvitegravir (C23H23ClFNO5, Mr = 447.9 g/mol) is a dihydroquinolone derivative. It … Elvitegravir

Cobicistat

Products Cobicistat is commercially available as a monopreparation (Tybost) and as a fixed combination with elvitegravir, emtricitabine, and tenofovirdisoproxil in the form of film-coated tablets (Stribild). It has been approved in many countries since 2013. Other combination products exist with darunavir (Rezolsta) and with atazanavir (Evotaz). Structure and properties Cobicistat (C40H53N7O5S2, Mr = 776.0 g/mol) … Cobicistat

Antiviralia

Products Direct antiviralia are commercially available as drugs in the form of tablets, capsules, solutions, and creams, among others. The first antiviral agent was approved in the 1960s (idoxuridine). Structure and properties Antivirala are a large group of drugs and have no uniform chemical structure. However, groups can be formed, such as the nucleoside analogs. … Antiviralia

Emtricitabine

Products Emtricitabine is commercially available as a monopreparation in the form of capsules and as an oral solution (Emtriva, combination products, generics). It has been approved in many countries since 2004. Structure and properties Emtricitabine (C8H10FN3O3S, Mr = 247.2 g/mol) is a thioanalog of cytidine with a fluorine atom at the 5-position. It exists as … Emtricitabine

CRISPR-Cas9

Genome editing With the CRISPR-Cas9 system, it has become possible to modify the genome of any organism – for example, a bacterium, an animal, a plant or that of a human being – in a targeted and precise manner. In this context, one also speaks of genome editing and genome surgery. The method was first … CRISPR-Cas9

Condoms: Effect, Uses & Risks

Condoms are aids to contraception and to avoid transmission of sexually transmitted diseases. The thin rubber sheaths are slipped over the erect penis, preventing sperm from entering the female body. Condoms are among the most popular contraceptives because they are considered relatively safe when used properly. What are condoms? Condoms are thin rubber latex sheaths … Condoms: Effect, Uses & Risks

Tipranavir: Effects, Uses & Risks

The active medical ingredient Tipranavir is a drug that is used to treat people with HIV type 1. It is used as part of a combination antiretroviral therapy. The drug Tipranavir is available on the pharmacological market under the trade name Aptivus and is distributed by the producer Boehringer. The active ingredient tipranavir is considered … Tipranavir: Effects, Uses & Risks

Corner of the Mouth Cracks

Symptoms Mouth corner rhagades manifest as inflamed tears in the area of the corners of the mouth. The symptoms are often bilateral and and often involve the adjacent skin. Other symptoms include redness, scaling, pain, itching, crusting and dehydration. Mouth cracks are uncomfortable, bothersome and often slow to heal. Causes Typical causes and risk factors … Corner of the Mouth Cracks

Vaginal Fungus

Symptoms Acute, uncomplicated vaginal mycosis occurs more frequently in women of childbearing age. In contrast, it is rare in girls and postmenopausal women. About 75% of all women contract vaginal mycosis once in their lives. The clinical manifestation varies. Possible symptoms include: Itching and burning (leading symptoms). Inflammation of the vagina and vulva with symptoms … Vaginal Fungus