Products Dinutuximab was approved in the United States and the EU in 2015 as a concentrate for the preparation of an infusion solution (Unituxin). It has not yet been registered in many countries. Structure and properties Dinutuximab is a chimeric monoclonal antibody (human/mouse). Effects Dinutuximab (ATC L01XC16) has cytotoxic properties. It binds to ganglioside GD2, … Dinutuximab
Rabbit starvation, also known as rabbit emaciation, is a type of malnutrition that is not common today. It occurred primarily among hunting Native Americans, but also among early naturalists who relied on hunted animals as a food source for extended periods of time. In modern society, some diets based on high levels of protein in … Rabbit Starvation: Causes, Symptoms & Treatment
Products Cilazapril is commercially available in the form of film-coated tablets (Inhibace). Fixed combinations with hydrochlorothiazide are available (Inhibace plus). Cilazapril has been approved in many countries since 1990. Structure and properties Cilazapril (C22H31N3O5, Mr = 417.5 g/mol) exists as a white crystalline powder that is sparingly soluble in water. It is a prodrug that … Cilazapril
Products Propranolol is commercially available in tablet, sustained-release capsule, and solution forms (Inderal, generic, hemangiol). It has been approved in many countries since 1965. Structure and properties Propranolol (C16H21NO2, 259.34 g/mol) is present in drugs as propranolol hydrochloride, a white powder that is soluble in water. Propranolol is a racemate. The -enantiomer is predominantly active. … Propranolol
Products Regadenoson is commercially available as a solution for injection (Rapiscan). It was approved in the United States in 2008, in the EU in 2010, and in many countries in 2017. Structure and properties Regadenoson (C15H18N8O5, Mr = 390.4 g/mol) is present in the drug as a monohydrate. It is a derivative of adenosine. Effects … Regadenoson
Products Nicorandil is commercially available in tablet form (Dancor). It has been approved in many countries since 1993. Structure and properties Nicorandil (C8H9N3O4, Mr = 211.2 g/mol), like nitroglycerin, is an organic nitrate. It is a combination of the vitamin nicotinamide with an ethyl nitrate. Effects Nicorandil (ATC C01DX16) has vasodilator, antihypertensive, and cardioprotective properties. … Nicorandil
Several messenger substances that have a positive effect on the body’s well-being are referred to as happiness hormones. Serotonin, dopamine, and endorphins are thought to relieve pain, induce states of relaxation, and make people happy. Because of their effects on the psyche, which are comparable to narcotics, happiness hormones are also referred to as endogenous … Happiness Hormones: Function & Diseases
Broom broom is a plant species that belongs to the butterfly family (Faboideae). However, it has nothing to do with the brooms (Genista), but is assigned to the honeysuckle (Cytisus). It is used in various fields, including as an ornamental plant and in folk medicine. Occurrence and cultivation of broom broom In folk medicine, broom … Broom: Applications, Treatments, Health Benefits
Products Barbiturates are commercially available in many countries in tablet and injectable forms. Few drugs are still available because barbiturates have become less important after the introduction of benzodiazepines and other psychotropic drugs. Barbiturates were most commonly used in the first half of the 20th century. Barbiturates were synthesized as early as the 19th century. … Barbiturates
Products Esmolol is commercially available as an injection and infusion solution (Brevibloc, generic). It has been approved in many countries since 1990. Structure and properties Esmolol (C16H25NO4, Mr = 295.4 g/mol) is present in drugs as esmolol hydrochloride, a racemate and a white crystalline powder that is highly soluble in water. It is rapidly biotransformed … Esmolol
Products Tisagenlecleucel (Kymriah, cell suspension for infusion) was approved as the first gene therapy in the United States in 2017 and in the EU and many countries in 2018. The drug was originally developed by Novartis at the University of Pennsylvania. The high price of the therapy is controversial. Mechanism of action Tisagenlecleucel is a … Tisagenlecleucel
Products Nitrates are commercially available in the form of chewable capsules, transdermal patches, infusion preparations, ointment, sustained-release tablets, sustained-release capsules, and sprays. As the first representative, nitroglycerin was already produced in the 19th century and used for the treatment of angina pectoris. Nitrates are thus among the oldest synthetic drugs. Structure and properties Organic nitrates … Organic Nitrates
