Products Topotecan is commercially available in capsule form and as a lyophilizate (Hycamtin, generic). It has been approved in many countries since 1996. Structure and properties Topotecan (C23H23N3O5, Mr = 421.4 g/mol) is present in the drug as topotecan hydrochloride. It is a semisynthetic derivative of camptothecin, a plant alkaloid derived from the tree. Effects … Topotecan
Products Irinotecan is commercially available as an infusion concentrate (Campto, generic). It has been approved in many countries since 1998. In 2017, the nanoliposomal formulation irinotecan sucrosofate was released (Onivyde). Structure and properties Irinotecan (C33H38N4O6, Mr = 586.7 g/mol) is a semisynthetic derivative of camptothecin, a plant alkaloid derived from the tree. In the drug … Irinotecan
Products Irinotecansucrosofate was approved in many countries in 2017 as a concentrate for the preparation of an infusion solution (Onivyde). Structure and properties Irinotecansucrosofate is a nanoliposomal formulation of irinotecan. The drug is present enclosed in liposomes and therefore has a much longer half-life than irinotecan. The formulation may also contribute to lower toxicity and … Irinotecansucrosofate
Symptoms The possible initial symptoms of colon cancer include: Change in bowel habits, diarrhea or constipation. Bleeding, blood in the stool, black colored stool. Frequent urge to defecate, discharge of small and thin portions. Abdominal pain, flatulence, cramps. Weight loss, weakness, anemia Because the cancer grows slowly, it takes years before clinical symptoms finally appear. … Colon Cancer: Causes and Treatment
Background The human organism has several mechanisms to metabolize endogenous and foreign substances. One of these mechanisms is glucuronidation, which occurs primarily in the liver. In this process, enzymes from the superfamily of UDP-glucuronosyltransferases (UGT) transfer a molecule of glucuronic acid from UDP-glucuronic acid to the substrate. Using acetaminophen as an example, alcohols, phenols, carboxylic … Meulengracht’s Disease
Symptoms Lung cancer may initially be asymptomatic. It is often discovered only when it is no longer curable. Possible typical symptoms include a chronic cough, coughing up blood, difficulty breathing, recurrent colds, chest pain, and weakness, fatigue, lack of appetite, and weight loss. If spread further, additional symptoms include hoarseness, noises when breathing, and difficulty … Lung Cancer Causes and Treatment
