Symptoms Rheumatoid arthritis is a chronic, inflammatory and systemic joint disease. It manifests as pain, symmetrically tense, achy, warm, and swollen joints, swelling, and morning stiffness that lasts for more than an hour. Initially, the hands, wrists, and feet are most affected, but later numerous other joints are also affected. Over time, deformities and rheumatoid … Rheumatoid Arthritis Causes and Treatment
What are prodrugs? Not all active pharmaceutical ingredients are directly active. Some must first be converted to the active substance by an enzymatic or non-enzymatic conversion step in the body. These are the so-called . The term was introduced by Adrien Albert in 1958. It is estimated that up to 10% of all active ingredients … Prodrugs
Products Teriflunomide is commercially available in the form of film-coated tablets (Aubagio). It was approved in many countries in 2013. Teriflunomide can be taken perorally, unlike earlier MS medications, and does not need to be injected. Structure and properties Teriflunomide (C12H9F3N2O2, Mr = 270.2 g/mol) is the active metabolite of the prodrug leflunomide (Arava), which … Teriflunomide
Products Leflunomide is commercially available in the form of film-coated tablets (Arava, generics). It has been approved in many countries since 1998. In 2011, generic versions went on sale in many countries. Structure and properties Leflunomide (C12H9F3N2O2, Mr = 270.2 g/mol) is an isoxazole carboxamide. It is a prodrug and is biotransformed in the intestine … Leflunomide