Products Vaborbactam was approved in the United States in 2017 as a fixed combination with the antibiotic meropenem (Vabomere, The Medicines Company). Meropenem belongs to the carbapenems and beta-lactam antibiotics group. Structure and properties Vaborbactam (C12H16BNO5S, Mr = 297.1 g/mol) is a cyclic boron compound and a boronic acid derivative. It is not a representative … Vaborbactam
Effects Carbapenems (ATC J01DH) are bactericidal against aerobic and anaerobic Gram-positive and Gram-negative pathogens. Effects are based on binding to penicillin-binding proteins (PBP) and inhibition of bacterial cell wall synthesis, resulting in bacterial dissolution and death. Imipenem, the first representative of the drug group, is degraded by the renal enzyme dehydropeptidase-I (DHP-I). It is therefore … Carbapeneme
Products Antibiotics (singular: antibiotic) are commercially available in the form of tablets, dispersible tablets, capsules, as infusion preparations, suspensions and syrups for children, and as granules, among others. There are also some topical preparations, such as creams, ointments, eye drops, eye ointments, ear drops, nasal ointments and sore throat tablets. The first active ingredient from … Antibiotics: Antibacterial Drugs
Products Meropenem is commercially available as a powder for solution for injection/infusion (Meronem, generic). It has been approved in many countries since 1995. The antibiotic is also combined with the beta-lactamase inhibitor vaborbactam. Structure and properties Meropenem (C17H25N3O5S, Mr = 383.5 g/mol) is present in drugs as meropenem trihydrate, a white to slightly yellowish crystalline … Meropenem
Meropenem is an antibiotic that belongs to the group of carbapenems. The drug is used primarily in the context of the therapy of bacterial infections. Among other things, the fact that meropenem is effective against both gram-negative and gram-positive germs and bacteria is exploited. In the majority of cases, the drug is administered by intravenous … Meropenem: Effects, Uses & Risks
