Inhaled Glucocorticoids

Effects Glucocorticoids (ATC R03BA02) have anti-inflammatory, antiallergic, and immunosuppressive properties. The effects are based on binding to intracellular receptors, resulting in an influence on protein expression. In addition, glucocorticoids also exert extragenomic effects. All agents are lipophilic (virtually insoluble in water) and thus enter cells well across the cell membrane. Indications For the treatment of … Inhaled Glucocorticoids

Fenoterol

Products Fenoterol is commercially available in combination with ipratropium bromide as a metered-dose inhaler (Berodual N). Berotec N is no longer on the market. Fenoterol has been approved in many countries since 2000. Structure and properties Fenoterol is present in drugs as fenoterol hydrobromide (C17H22BrNO4, Mr = 384.3 g/mol) is present, a white crystalline powder … Fenoterol

Ipratropium Bromide

Products Ipratropium bromide is commercially available as an inhalation solution, metered-dose inhaler, and nasal spray (Atrovent, Rhinovent, generics). Combination preparations with beta2-sympathomimetics are also commercially available (Dospir, Berodual N, generics). Pharmacies also produce inhalation solutions with ipratropium bromide as extemporaneous preparations. The active ingredient has been approved in many countries since 1978. Structure and properties … Ipratropium Bromide

Upstream Chambers

Application Compose chamber Spray appropriate number of doses into chamber with metered dose inhaler Exhale Taking a deep breath, holding the breath Clean regularly according to the package insert Selected products Able Spacer Aerochamber: GlaxoSmithKline (Ventolin, Axotide) Babyhaler by GlaxoSmithKline Fisonair (Sanofi-Aventis) Nebuhaler (Bricanyl and Pulmicort, out of trade). Pari Vortex Volumatic (GlaxoSmithKline, out of … Upstream Chambers