Products Olodaterol was approved in many countries in 2014 as a solution for inhalation (Striverdi). In 2016, a fixed-dose combination with tiotropium bromide was also marketed (Spiolto). Both drugs are administered with the Respimat. Respimat The Respimat is a new inhalation device that releases a visible spray, or aerosol. The droplets are fine and move … Olodaterol
Products Formoterol is commercially available in the form of capsules for inhalation (Foradil) and as a powder inhaler (Oxis). Furthermore, combination products with budesonide (Symbicort Turbuhaler, Vannair Dosieraerosol) and fluticasone propionate are available (Formoterol Dosieraerosol). Formoterol is also combined with beclometasone fixed, see under beclometasone and formoterol (Foster). Furthermore, in 2020, a fixed combination with … Formoterol
Products Hexoprenaline is commercially available as a solution for injection (Gynipral). It has been approved in many countries since 1984. Approval for the tablets was revoked on Dec. 31, 2013. This due to the potential cardiovascular side effects that may occur in the mother and child. Structure and properties Hexoprenaline (C22H32N2O6, Mr = 420.5 g/mol) … Hexoprenaline
Products LABA is an acronym for , which means long-acting beta agonists (sympathomimetics). LABAs are mainly marketed as inhaled preparations (powders, solutions) administered with an inhaler such as a metered-dose inhaler, diskus, respimat, breezhaler, or ellipta. Some may also be given perorally. Salmeterol and formoterol were the first agents from this group to be approved … LABA
Products Bambuterol is commercially available in the form of tablets (Bambec). The drug is not registered in many countries. Structure and properties Bambuterol (C18H29N3O5, Mr = 367.4 g/mol) is present in drugs as bambuterol hydrochloride. It is a prodrug of terbutaline. Effects Bambuterol (ATC R03CC12) is bronchodilator. Its effects are due to stimulation of adrenergic … Bambuterol
Products Fenoterol is commercially available in combination with ipratropium bromide as a metered-dose inhaler (Berodual N). Berotec N is no longer on the market. Fenoterol has been approved in many countries since 2000. Structure and properties Fenoterol is present in drugs as fenoterol hydrobromide (C17H22BrNO4, Mr = 384.3 g/mol) is present, a white crystalline powder … Fenoterol
Products The fixed combination of beclomethasone dipropionate and formoterol was approved in many countries in 2019 in the form of a metered-dose inhaler with a compressed-gas inhalation solution. In other countries, the drug has been registered for longer, for example in Germany since 2006. The powder inhalers have not yet been approved in many countries. … Beclometasone and Formoterol
Products Vilanterol is commercially available as a fixed combination with fluticasone furoate in powder inhaler form (Relvar Ellipta / Breo Ellipta). It was approved in the US and EU in 2013 and in many countries in 2014. The fixed combination with umeclidinium bromide (Anoro Ellipta) was also registered in many countries in 2014. In 2017, … Vilanterol
Products Pirbuterol is available as a drug for inhalation in some countries (e.g., USA, Maxair). The drug is no longer approved in many countries. Structure and properties Pirbuterol (C12H20N2O3, Mr = 240.3 g/mol) is a pyridine derivative closely related structurally to salbutamol (Ventolin, generics), differing from it only in one nitrogen atom. It is present … Pirbuterol
Products Terbutaline is commercially available as a turbuhaler and has been approved in many countries since 1987 (Bricanyl). The syrup is out of commerce. Other dosage forms are available in other countries (e.g., tablets, solution for injection). Structure and properties Terbutaline (C12H19NO3, Mr = 225.3 g/mol) is present in drugs as terbutaline sulfate, a white … Terbutaline
Products Salmeterol is commercially available as metered-dose inhalers and discs (Serevent, Seretide + fluticasone). It has been approved in many countries since 1995. Structure and properties Salmeterol (C25H37NO4, Mr = 415.6) is present in the drugs as a racemate and as salmeterol xinafoate, a white powder that is sparingly soluble in water. It is structurally … Salmeterol
Products Indacaterol is commercially available as hard capsules with a powder for inhalation (Onbrez Breezhaler) and has been approved since 2010. It is also combined fixed with the LAMA glycopyrronium bromide (Ultibro Breezhaler, approved 2014). The fixed combination with mometasone furoate (Atectura Breezhaler) was registered for asthma therapy in 2020. Finally, a combination of indacaterol … Indacaterol
