Send SSRI Abrupt SSRIs are generally not recommended. The body is accustomed to a fairly constant serotonin level during the intake of SSRI. If a patient suddenly stops taking the drug, the serotonin level also drops very quickly. The reason for this is the short half-life of the medication. Half-life is the time it takes … Send SSRI | SSRI
Alternatives to SSRI Antidepressants can have serious side effects that require a change. In addition to SSRIs, the class of antidepressants includes the so-called tricyclic antidepressants. Active ingredients in this group include amitriptyline, imipramine, clomipramine and others. However, due to their numerous side effects, they are no longer considered the first choice in the treatment … Alternatives to SSRI | SSRI
Products Mianserin is commercially available in the form of film-coated tablets (generic). It was approved in many countries in 1981. The original Tolvon is no longer marketed. Structure and properties Mianserin (C18H20N2, Mr = 264.4 g/mol) is structurally and pharmacologically closely related to mirtazapine (Remeron, generics) and is present in the drug as mianserin hydrochloride, … Mianserin
Symptoms Sleep disorder refers to an undesirable change in the usual sleep rhythm. This manifests itself in difficulty falling asleep or staying asleep, insomnia, a change in sleep profile, sleep length, or inadequate rest. Sufferers are unable to fall asleep for long periods in the evening, wake up at night or early in the morning, … Sleep Disorders
Physiological background Itch results from activation of specialized afferent unmyelinated C fibers in the skin. These fibers are anatomically identical to those that conduct pain but differ in function and stimulus transmission to the brain. They contain a number of receptors such as histamine receptors, PAR-2, endothelin receptor, and TRPV1, and mediators such as histamine, … Itch
What should be considered when weaning? Patients treated with SNRI should not discontinue or change the dose without consulting their doctor. SNRI should never be stopped suddenly. This can lead to life-threatening side effects. These include symptoms such as fatigue, dizziness, headache, drowsiness or confusion, diarrhea, nausea, nervousness, agitation, or discomfort. Seizures are also possible … What should be considered when weaning? | SNRI
Introduction The so-called serotonin noradrenaline reuptake inhibitors (SNRI) are mainly drugs used in the treatment of depression. The most important active ingredients in this class of drugs are venlafaxine and duloxetine. The name refers to the ability of these drugs to exert their effect on both serotonin and noradrenalin levels in the central nervous system. … SNRI
Effect of SNRI As described above and as can be seen from the name, serotonin noradrenalin reuptake inhibitors (SNRI) inhibit the reuptake of serotonin and noradrenalin into the nerve cells. In order to understand this mechanism, one should consider the structure of a synapse, i.e. an interconnection point between two nerve cells. A synapse consists … Effect of SNRI | SNRI
When should SNRI not be given? SNRIs must not be used if an intolerance and allergic reaction to the active substance has occurred. The use of so-called MAOIs, the irreversible monoamine oxidase inhibitors, is also considered a strict contraindication.These are drugs used to treat depression or Parkinson’s disease. If taken at the same time or … When should SNRI not be given? | SNRI
SNRI during pregnancy Pregnancy and antidepressants are two closely interwoven topics, as numerous studies have shown that the incidence of depression is significantly higher among pregnant women and women in the puerperium than in the general population. The most important piece of advice regarding pregnancy during depression treatment is to tell your doctor that you … SNRI during pregnancy | SNRI
Introduction Due to its chemical structure, mirtazapine is one of the so-called tetracyclic antidepressants, i.e. drugs used to treat depression. In Germany it is marketed under the trade name Remergil®. It is a prescription-only preparation, which is available in various strengths and dosage forms. There are film-coated tablets containing 15 mg, 30 mg or 45 … Mirtazapine
Interactions The interactions of mirtazapine with other drugs are minimal. The antiepileptic drugs carbamazepine and phenytoin can speed up the breakdown of mirtazapine in the body, which can possibly lead to an increase in the dose of mirtazapine. If mirtazapine is taken together with lithium, which also has an antidepressant effect, the effects and side … Interactions | Mirtazapine
