How misoprostol works Misoprostol is a synthetically produced derivative of the tissue hormone prostaglandin E1 (i.e. a so-called prostaglandin E1 analog). It can dock onto certain glandular cells of the gastric mucosa (parietal cells) and thus inhibit the release of gastric acid. This can help to prevent acid-related ulcers in the stomach and duodenum. The … Misoprostol: Effects, Application, Side Effects
Products Misoprostol tablets for medication abortion were approved in many countries in 2015 (MisoOne). This article refers to abortion. In addition, other drugs exist with other indications (gastric protection, induction of labor). Structure and properties Misoprostol (C22H38O5, Mr = 382.5 g/mol) is a synthetic derivative of prostaglandin E1 and exists as a mixture of two … Misoprostol
Drug induction of labor Induction of labor may be indicated for a variety of reasons, such as premature rupture of the membranes, gestational hypertension, or if the due date has passed. Several medications are available, which are usually administered intravenously, vaginally, or cervically: Oxytocin: Is a natural hormone of the pituitary gland that is secreted … Birth Induction
Products Dinoprostone is commercially available as a vaginal insert and vaginal tablet (Propess, Prostin E2). It is also available as a vaginal gel and vaginal suppository in some countries. Dinoprostone has been approved in many countries since 1986. Structure and properties Dinoprostone (C20H32O5, Mr = 352.5 g/mol) corresponds to the natural prostaglandin E2. It exists … Dinoprostone
Drug gastric protection Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used for acute and long-term treatment of painful and inflammatory conditions. Active ingredients used include, for example, diclofenac, acetylsalicylic acid, ibuprofen, naproxen, and mefenamic acid. However, their use is limited by adverse effects that affect the upper digestive tract and are due to inhibition of prostaglandin … Stomach Protection
Products Mifepristone is commercially available in tablet form (Mifegyne). It was first approved in 1988 and in many countries in 1999. Mifepristone was discovered in the 1980s at Roussel-Uclaf (RU) during the development of antiglucocorticoid agents and is therefore also known as RU 486. Structure and properties Mifepristone (C29H35NO2, Mr = 429.6 g/mol) is a … Mifepristone
