Products Acamprosate is commercially available in the form of enteric-coated film-coated tablets (Campral). The active ingredient has been approved in many countries since 1995. Structure and properties Acamprosate (C5H11NO4S, Mr =181.2 g/mol) is present in drugs as acamprosate calcium, a white powder that is readily soluble in water. It has structural similarities to the neurotransmitter … Acamprosate
Effects Antiadiposita differ in their effects. They inhibit appetite or increase satiety, reduce the absorption of food components in the intestine or promote their utilization, increase energy metabolism and degrading metabolic processes. The ideal slimming agent would enable rapid, high and stable weight loss and at the same time be very well tolerated and applicable … Slimming Products
Naltrexone is a drug in the opioid antagonist group. The prescription drug is used in opioid withdrawal. What is naltrexone? Naltrexone is used in opioid addiction withdrawal and alcohol addiction treatment. Naltrexone is an opioid antagonist. Opioid antagonists are drugs that bind to opioid receptors and can partially or completely reverse the effects of opioids. … Naltrexone: Effects, Uses & Risks
Products Nalmefene is commercially available in the form of film-coated tablets (Selincro). It was registered in many countries in 2014. Structure and properties Nalmefene (C21H25NO3, Mr = 339.4 g/mol) is structurally closely related to naltrexone, from which it is derived. In the drug product, it is present as nalmefene hydrochloride and dihydrate, a white crystalline … Nalmefene
Products Methylnaltrexone is commercially available as a solution for injection (Relistor). It has been approved in many countries since 2009. Structure and properties Methylnaltrexone (C21H26NO4, Mr = 356.4 g/mol) is an -methylated naltrexone. It is present in drugs as methylnaltrexone bromide. Effects Methylnaltrexone (ATC A06AH01) counteracts constipation caused by opioids. The effects are due to … Methylnaltrexone
Products Disulfiram is commercially available in the form of water-suspendable tablets called dispersible tablets (Antabus). It has been approved in many countries since 1949. Structure and properties Disulfiram or tetraethylthiuram disulfide (C10H20N2S4, Mr = 296.54 g/mol) is a white to almost white crystalline powder that is practically insoluble in water. Prior to its medical use, … Disulfiram
Effects Dopamine antagonists are antidopaminergic, antipsychotic, antiemetic, and prokinetic. They are antagonists at dopamine receptors, eg, dopamine (D2)-receptors, thus abolishing the effects of the neurotransmitter dopamine. Indications Psychotic disorders Nausea and vomiting, to promote gastric emptying and motility in the gastrointestinal tract. Some dopamine antagonists are also used to treat movement disorders (dyskinesias, including neuroleptic-induced), … Dopamine Antagonists
Physiological background Itch results from activation of specialized afferent unmyelinated C fibers in the skin. These fibers are anatomically identical to those that conduct pain but differ in function and stimulus transmission to the brain. They contain a number of receptors such as histamine receptors, PAR-2, endothelin receptor, and TRPV1, and mediators such as histamine, … Itch
Products Bremelanotide was approved in the United States in 2019 as an injection solution in an auto-injector pen (Vyleesi). Structure and properties Bremelanotide (C50H68N14O10, Mr = 1025.2 g/mol) is a synthetic cyclic peptide analog of α-melanocyte stimulating hormone (α-MSH) produced in the adenohypophysis. Bremelanotide consists of seven amino acids (heptapeptide) and is an active metabolite … Bremelanotide
Products Naloxone is commercially available as a solution for injection (Naloxone OrPha, Naloxone Actavis) and has been approved in many countries since 2004. Information on combination with oxycodone is presented under the article Oxycodone and Naloxone (Targin, Peroral). As a fixed combination with buprenorphine, naloxone is used to treat opioid dependence (Suboxone, sublingual). In 2014, … Naloxone
Products Naltrexone is commercially available in the form of film-coated tablets (naltrexin). It has been approved in many countries since 2003. Structure and properties Naltrexone (C20H23NO4, Mr = 341.40 g/mol) is a synthetically produced opioid related to oxymorphone. It is present in drugs as naltrexone hydrochloride, a white, hygroscopic powder that is readily soluble in … Naltrexone
