nk1 receptor antagonists

Antiemetics: Drugs against Nausea or Vomiting

Products Antiemetics are commercially available in the form of tablets, as melting tablets, as solutions (drops), and injectables, among others. They are also administered as suppositories because peroral administration is not possible. In many countries, the best-known antiemetics include domperidone (Motilium, generic) and meclozine, which, along with caffeine and pyridoxine, is contained in Itinerol B6. … Antiemetics: Drugs against Nausea or Vomiting

Aprepitant

Products Aprepitant is commercially available in the form of capsules (Emend). It has been approved in many countries since 2003. Structure and properties Aprepitant (C23H21F7N4O3, Mr = 534.4 g/mol) is a morpholine and triazol-3-one derivative. It exists as a white crystalline powder that is practically insoluble in water. For intravenous use, the more water-soluble prodrug … Aprepitant

Nausea and Vomiting

Symptoms Nausea is an unpleasant and painless sensation that can lead to vomiting. Vomiting is an autonomic response of the body in which the stomach contents are expelled through the mouth with contraction of the muscles. Its primary purpose is to protect the body from toxic and inedible foods and harmful substances. Nausea may be … Nausea and Vomiting

Rolapitant

Products Rolapitant was approved in the form of film-coated tablets in the United States in 2015, in the EU in 2017, and in many countries in 2018 (Varuby). Structure and properties Rolapitant (C25H26F6N2O2, Mr = 500.5 g/mol) is present in the drug as rolapitane hydrochloride, a white powder that is more soluble in water at … Rolapitant

Fosaprepitant

Products Fosaprepitant is commercially available as an infusion preparation (Ivemend). It has been approved in many countries since 2008. Structure and properties Fosaprepitant (C23H22F7N4O6P, Mr = 614.4 g/mol) is the prodrug of aprepitant (Emend). Unlike aprepitant, which is administered orally, fosaprepitant is administered parenterally and is more water soluble. Detailed information See under aprepitant

Maropitant

Products Maropitant is commercially available as a solution for injection and in tablet form as a veterinary drug (Cerenia). It has been approved in many countries since 2008. Structure and properties Maropitant (C38H50N2O9, Mr = 678.8 g/mol) Effects Maropitant (ATCvet QA04AD90) has antiemetic properties. The effects are due to inhibition of substance P binding to … Maropitant