Definition In drug therapy, “off-label use” refers to deviations from the officially approved specifications in the drug information leaflet of approved drugs that are ready for use. Frequently, this concerns the areas of application (indications). However, other changes also fall under the definition, for example with regard to the dose, duration of therapy, patient groups, … Off-Label Use
Products Transdermal patches are approved as medicinal products. They offer themselves as an alternative to other modes of application such as peroral and parenteral administration. The first products were launched in the 1970s. Structure and properties Transdermal patches are flexible pharmaceutical preparations of varying sizes and thinness that contain one or more active ingredients. They … Transdermal Patches
Products Carbamazepine is commercially available as tablets, sustained-release tablets, suspension, and syrup (Tegretol, generics). It has been approved in many countries since 1963. Structure and properties Carbamazepine (C15H12N2O, Mr = 236.3 g/mol) exists as a white crystalline powder that is very sparingly soluble in water. It has a tricyclic structure and an active metabolite, carbmazepine-10,11-epoxide. … Carbamazepine Effects and Side Effects
Products Favipiravir is approved in Japan in the form of film-coated tablets (Avigan). Structure and properties Favipiravir (C5H4FN3O2, Mr = 157.1 g/mol) is a fluorinated pyrazine carboxamide derivative. It is a prodrug that is biotransformed in cells to the active metabolite favipiravir-RTP (favipiravir-ribofuranosyl-5′-triphosphate), a purine nucleotide analog. Favipiravir exists as a white to slightly yellow … Favipiravir
Products Hydroxychloroquine is commercially available in the form of film-coated tablets (Plaquenil, auto-generic: Hydroxychloroquine Zentiva). It has been approved in many countries since 1998. Unlike the closely related chloroquine, it is currently on sale. Generic drugs are registered. Structure and properties Hydroxychloroquine (C18H26ClN3O, Mr = 335.9 g/mol) is an aminoquinoline derivative. It is present in … Hydroxychloroquine
Products Stimulants are commercially available as drugs, narcotics, dietary supplements, and foods. Dosage forms include tablets, capsules, and solutions. Structure and properties Stimulants do not have a uniform chemical structure, but groups can be identified. Many, for example the amphetamines, are derived from the natural catecholamines such as epinephrine and norepinephrine. Effects The active ingredients … Stimulants
Products Ivermectin is commercially available in some countries in tablet form (Stromectol). It has not yet been registered in many countries and therefore must be imported from abroad if needed. Ivermectin has been used medicinally since the 1980s, initially primarily as a veterinary drug. This article refers to peroral administration in humans. See also under … Ivermectin
Products Mefloquine is commercially available in the form of film-coated tablets (generic: mephaquine). The active ingredient was approved in many countries in 1984. Distribution of the original Lariam (Roche) was discontinued in 2014 for commercial reasons. Structure and properties Mefloquine (C17H16F6N2O, Mr = 378.3 g/mol) is a fluorinated quinoline and piperidine derivative and an analog … Mefloquine
Products Camostat is not commercially available in many countries. It is approved in Japan in tablet form (Foipan). Structure and properties Camostat (C20H22N4O5, Mr = 398.4 g/mol) is present in the drug in the form of the salt camostat mesilate, a white crystalline powder that is sparingly soluble in water. It is metabolized by ester … Camostat
Definition Most drugs today are pre-produced in large quantities and enter the market ready for use. However, drugs also exist that are produced in the laboratory by pharmacies on a doctor’s prescription for individual customers. These are referred to as extemporaneous preparations. The following is the definition according to the Federal Law on Medicinal Products … Magisterial Recipes
Products Lopinavir is commercially available as film-coated tablets and as a syrup as a fixed combination with ritonavir (Kaletra). It has been approved in many countries since 2000. Structure and properties Lopinavir (C37H48N4O5, Mr = 628.8 g/mol) exists as a white to yellowish white powder that is practically insoluble in water. Effects Lopinavir (ATC J05AE06) … Lopinavir
Products Ruxolitinib was approved in tablet form in the United States in 2011 and in the EU and Switzerland in 2012 (Jakavi). Structure and properties Ruxolitinib (C17H21N6O4P, Mr = 404.4 g/mol) is present in drugs as ruxolitinib phosphate, a white to light pink powder that is soluble in water. It is a pyrrolopyrimidine pyrazole derivative … Ruxolitinib
