Products Netarsudil was approved in the United States in 2017 in eye drop form (Rhopressa, Rhokiinsa). Structure and properties Netarsudil (C28H27N3O3, Mr = 453.5 g/mol) is present in the drug as netarsudil dimesilate, slightly yellowish to white powder soluble in water. Effects Netarsudil lowers intraocular pressure by enhancing aqueous humor outflow at the trabecular meshwork. … Netarsudil
Products Brinzolamide is form of eye drops commercially available (Azopt) and approved in many countries since 1991. Generic versions were released in 2015. Brinzolamide has also been available in a fixed combination with timolol since 2009 (Azarga). In 2015, a fixed combination with brimonidine was approved; see brinzolamide brimonidine (Simbrinza). Structure and properties Brinzolamide (C12H21N3O5S3, … Brinzolamide
Products Prostaglandin analogues are commercially available in the form of eye drops in vials or as monodoses without preservatives. Latanoprost (Xalatan) was the first agent from this group to be approved in 1996. Prostaglandin analogues are also combined with the beta-blocker timolol fix. Structure and properties Prostaglandin analogs are derivatives of prostaglandin F2α. Except for … Prostaglandin Analogs
Products Travoprost is commercially available in the form of eye drops as a monopreparation (Travatan) and as a fixed combination with the beta-blocker timolol (Duotrav). It was approved in many countries in 2002. Generic versions were first released in 2016 and went on sale in 2017. Structure and properties Travoprost (C26H35F3O6, Mr = 500.55 g/mol) … Travoprost
Products Tafluprost is available in the form of eye drops (saflutane). It was approved in many countries in 2010. In 2016, a fixed combination with timolol was also registered (Taptiqom). Structure and properties Tafluprost (C25H34F2O5, Mr = 452.53 g/mol) is a fluorinated analog of prostaglandin F2α (Figure). It is a prodrug and is converted at … Tafluprost
Products Latanoprost is commercially available as eye drops in dropper bottles and as monodoses (Xalatan, generic, auto-generic, 50 µg/ml). It is also available as a fixed combination with timolol (Xalacom, generic, auto-generic). Latanoprost was developed in the 1980s as part of a collaboration between Columbia University in New York and Pharmacia in Uppsala, Sweden (Stjernschantz, … Latanoprost
Products Latanoprostenebunod was approved in the United States in 2017 in the form of eye drops (Vyzulta). Structure and properties Latanoprostenebunod is a prodrug that is metabolized in the eye to latanoprost acid and butanediol mononitrate. Butanediol mononitrate is further biotransformed to 1,4-butanediol and nitric oxide (NO). Latanoprost acid is also formed from latanoprost, which … Latanoprostenbunod
Products Bimatoprost is commercially available in the form of eye drops (Lumigan). It is also available in combination with timolol (Ganfort, Ganfort UD). The drug was approved in many countries in 2002. Generics are registered. Latisse (0.3 mg/ml) to promote eyelash growth is on the market in the United States. Structure and properties Bimatoprost (C25H37NO4, … Bimatoprost
