Products Sedatives are commercially available in the form of tablets, melting tablets, drops, as injectables and tinctures, among others. Structure and properties Sedatives do not have a uniform chemical structure. Effects The active ingredients have sedative properties. Some are additionally antianxiety, sleep-inducing, antipsychotic, antidepressant, and anticonvulsant. The effects are due to promotion of inhibitory mechanisms … Sedative
Products The narcotics are a group of centrally acting drugs and substances, which are strongly regulated and controlled by the state respectively by the drug and health authorities. This is primarily to prevent abuse and to protect the population from the undesirable effects and addiction. Certain narcotics – for example, many potent hallucinogens – are … Narcotics Effects and Side Effects
Symptoms The main symptoms are diarrhea with watery stools, cramps in the lower abdomen, and flushing, which is seizure-like severe facial redness or purplishness, although the neck or legs may also be affected. The untreated or undiagnosed disease can lead to valvular heart defect, telangiectasias, and pellagra (vitamin B2 deficiency). Causes Carcinoid syndrome is based … Carcinoid Syndrome
Products In many countries, no drugs containing carfentanil are on the market. The active ingredient is used in veterinary medicine (Wildnil). Legally, it belongs to narcotics. Structure and properties Carfentanil (C24H30N2O3, Mr = 394.5 g/mol) is structurally closely related to fentanyl, being 4-methoxycarbonylfentanyl. Carfentanil citrate is present in pharmaceuticals. The active ingredient was developed at … Carfentanil
Symptoms Oral thrush, or primary gingivostomatitis herpetica, occurs primarily in children between 6 months and 5 years of age and in young adults around 20 years of age and may also affect older adults. It manifests itself in the following symptoms, among others: Swollen cervical lymph nodes, aphthoid lesions and ulcerations in the mouth and … Mouth Rot
Definition So-called “creeping in” is a gradual increase in the dose of a drug over days or a few weeks. This is used to slowly accustom the patient to the drug and to test individual tolerability. Creeping in helps to avoid undesirable effects. The target dose may be predefined or determined individually. In the second … Gradual Increase of the Dose of a Drug
Products Lofexidine was approved in the United States in 2018 in film-coated tablet form (Lucemyra). In the United Kingdom, the agent was approved for the treatment of opioid withdrawal back in the early 1990s (UK: BritLofex). Structure and properties Lofexidine (C11H12Cl2N2O, Mr = 259.1 g/mol) is present in the drug as lofexidine hydrochloride, a white … Lofexidine
Most common mechanism of action Most drugs bind to a macromolecular target structure called a drug target. These are usually proteins such as receptors, transporters, channels, and enzymes, or nucleic acids. For example, opioids interact with endogenous opioid receptors to relieve pain. Targets can also be exogenous structures. Penicillins inhibit bacterial enzymes responsible for building … Mechanism of Action
Products Tramadol is commercially available in the form of tablets, capsules, melting tablets, drops, effervescent tablets, suppositories, and as a solution for injection. (Tramal, generic). Fixed combinations with acetaminophen are also available (Zaldiar, generic). Tramadol was developed by Grünenthal in Germany in 1962 and has been approved in many countries since 1977 and in the … Tramadol: Drug Effects, Side Effects, Dosage and Uses
Products Buprenorphine is commercially available as sublingual tablets, transdermal patch and injection solution, and depot injection solution (e.g., Temgesic, Transtec, Subutex, generics). It has been approved in many countries since 1979. Structure and properties Buprenorphine (C29H41NO4, Mr = 467.6 g/mol) is present in drugs as buprenorphine hydrochloride, a white crystalline powder that is sparingly soluble … Buprenorphine
Products Butamirate is commercially available as a syrup, drops, and depot tablets (e.g., NeoCitran cough suppressant, formerly Sinecod). It has been approved in many countries since 1965. Structure and properties Butamirate (C18H29NO3, Mr = 307.4 g/mol) is present in drugs as butamirate dihydrogen citrate. It has structural similarities to the antitussive butetamate. Butamirate is not … Butamirate
Products Prasugrel is commercially available in the form of film-coated tablets (Efient). It was approved in many countries, in the EU and in the US in 2009. Generic versions were registered in 2019. Structure and properties Prasugrel (C20H20FNO3S, Mr = 373.4 g/mol) belongs to the group of thienopyridines and exists as a hydrochloride as a … Prasugrel
