British Sir James Paget (1814-1899) was not only a gifted surgeon and pathologist, but also a brilliant orator and scientist. His medical practice, founded in 1852, was so successful that after a short time he became personal surgeon to Queen Victoria and, a few years later, to the Prince of Wales. Genius thinker Paget’s fame … Who was James Paget?
A malignant degeneration of the female breast tissue (lat. “mamma”) is called breast carcinoma. Especially in western countries breast cancer is the most common type of cancer and statistically speaking one in nine women will develop the cancer during her lifetime. The peak of the disease is around 45 years and the risk increases again … What is Paget’s disease?
Epidemiology It settles in or around the nipple. 0.5 to 5% of all tissue changes in the breast are Paget’s cancer. Usually the affected patients are between 40 and 50 years old, but rarely the cancer form Paget’s disease can also manifest itself in patients aged 20 years. The average age for the first manifestation … Epidemiology | What is Paget’s disease?
Trigger To date, the exact development of the cancer form “Paget’s disease” has not been determined, but two theories have been developed.One theory, currently considered the most likely, is that the cancer cells (called Paget cells) form a tumor in the breast, which then emerges through the surface and leads to visible skin changes on … Trigger | What is Paget’s disease?
Therapy Prognosis and therapy of Paget’s disease depend entirely on the stage and type of breast cancer. In the case of Paget’s disease, treating only the skin alteration is by no means sufficient and is not effective, since the cancer continues to grow in the breast tissue underneath. Prognosis/opportunity for healing Paget’s disease of the … Therapy | What is Paget’s disease?
In healthy bone, formation and degradation are in balance. This is disturbed in Paget’s disease. Many patients are symptom-free, while others experience various symptoms. Paget’s disease is named after its first describer, the British physician Sir James Paget. It is also called “Paget’s disease of the bone” (to distinguish it from Paget’s carcinoma, “Paget’s disease … Paget’s Disease: Symptoms, Diagnosis, Therapy
If Paget’s disease is suspected, an X-ray examination will usually confirm the diagnosis: The rapid, “sloppy” bone formation, structural changes, thickening and deformation of the bone tissue can be easily seen. A bone scintigraphy may be taken to show the increased metabolic activity in the bone. Supportive blood or urine tests are performed, which show … Paget’s Disease: Therapy and Diagnosis