Paroxetine: Effects, Uses & Risks

Paroxetine is an antidepressant medical substance that belongs to the group of selective serotonin reuptake inhibitors. The substance is used to treat mental disorders such as anxiety disorders, depression, or post-traumatic stress disorder. The active ingredient was developed by the English pharmaceutical company GlaxoSmithKline, based in London. What is paroxetine? Paroxetine is a highly effective … Paroxetine: Effects, Uses & Risks

Paroxetine

Products Paroxetine is commercially available as film-coated tablets and as a suspension (Deroxat, generic). It has been approved in many countries since 1993. Paroxetine is also marketed as Seroxat and Paxil in some countries. Slow-release paroxetine (CR) is not currently available in many countries. Structure and properties Paroxetine (C19H20FNO3, Mr = 329.4 g/mol) is present … Paroxetine

Restless Legs Syndrome Causes and Treatment

Symptoms Restless legs syndrome manifests as an uncomfortable and difficult-to-describe feeling in the legs and a strong urge to move the legs. Less commonly, the arms are also affected. The unilateral or bilateral insensations include, for example, a burning sensation, pain, pressing, creeping and a pulling sensation. The discomfort occurs mainly at rest, for example, … Restless Legs Syndrome Causes and Treatment

Irritable Bowel Syndrome Causes and Treatment

Symptoms Irritable bowel syndrome is a functional bowel disorder that manifests itself in the following persistent or recurrent symptoms: Lower abdominal pain or cramping Diarrhea and/or constipation Flatulence Change in bowel habits, impaired defecation. Incontinence, urge to defecate, feeling of incomplete emptying. The symptoms improve with defecation. Some patients suffer mainly from diarrhea, others from … Irritable Bowel Syndrome Causes and Treatment

Tamoxifen (Nolvadex): Drug Effects, Side Effects, Dosage and Uses

Products Tamoxifen is commercially available in the form of film-coated tablets (Nolvadex, generic). It was synthesized in 1962 and tested as a contraceptive (“morning-after pill”) but was not suitable for this purpose. It was first used as a breast cancer drug in the early 1970s. It has been approved in many countries since 1976. Structure … Tamoxifen (Nolvadex): Drug Effects, Side Effects, Dosage and Uses

Serotonin Syndrome: Causes and Treatment

Background Serotonin (5-hydroxytryptamine, 5-HT) is a neurotransmitter biosynthesized from the amino acid tryptophan by decarboxylation and hydroxylation. It binds to seven different families of the serotonin receptor (5-HT1 to 5-HT7) and elicits central and peripheral effects that affect mood, behavior, sleep-wake cycle, thermoregulation, pain perception, appetite, vomiting, muscles, and nerves, among others. Serotonin is vasoconstrictive … Serotonin Syndrome: Causes and Treatment

Floods

Symptoms A hot flash is a spontaneous feeling of warmth that may be accompanied by sweating, palpitations, flushing of the skin, feelings of anxiety, and subsequent chills, and lasts for a few minutes. The flushes affect mainly the head and upper body, but sometimes the whole body. The flushes often also occur at night, are … Floods

Itch

Physiological background Itch results from activation of specialized afferent unmyelinated C fibers in the skin. These fibers are anatomically identical to those that conduct pain but differ in function and stimulus transmission to the brain. They contain a number of receptors such as histamine receptors, PAR-2, endothelin receptor, and TRPV1, and mediators such as histamine, … Itch