Products Promazine is commercially available in the form of dragées (Prazine). It has been approved in many countries since 1957. Structure and properties Promazine (C17H20N2S, Mr = 284.4 g/mol) is present in drugs as promazine hydrochloride, a white crystalline powder that is very soluble in water. It is a dimethylamine derivative of phenothiazine and structurally … Promazine
Products Perphenazine was commercially available in the form of film-coated tablets (Trilafon). It was approved in many countries in 1957 and went out of commerce on 3/31/2013. Structure and properties Perphenazine (C21H26ClN3OS, Mr = 403.9 g/mol) is a piperidine derivative of phenothiazine. It exists as a white to yellowish white crystalline powder that is practically … Perphenazine
Products Tricyclic antidepressants are commercially available in many countries in the form of dragées, tablets, capsules, and drops. The first representative, imipramine, was developed at Geigy in Basel. Its antidepressant properties were discovered in the 1950s by Roland Kuhn at the psychiatric clinic in Münsterlingen (Thurgau). Imipramine was approved in many countries in 1958. Structure … Tricyclic Antidepressants
Products Medicines containing prochlorperazine are no longer registered in many countries, but other phenothiazines are available. Structure and properties Prochlorperazine (C20H24ClN3S, Mr = 373.9 g/mol) is present in drugs as prochlorperazine hydrogen maleate, a white to slightly yellowish crystalline powder that is very sparingly soluble in water. It is a chlorinated propylpiperazine derivative of phenothiazine. … Prochlorperazine
Products Chlorpromazine was commercially available in various oral and parenteral dosage forms (e.g., Chlorazine, Thorazine, Largactil, Megaphene). It was first used in the 1950s as one of the first synthetic antipsychotics. Today, it is no longer a registered drug in many countries. In some countries, chlorpromazine is still on the market. Structure and properties Chlorpromazine … Chlorpromazine
Products Oxomemazine is commercially available as syrups (Toplexil N syrup). It has been approved in many countries since 1966. In France, several drugs containing oxomemazine are on the market. Structure and properties Oxomemazine (C18H22N2S, Mr = 298.4 g/mol) is a phenothiazine closely related structurally to the neuroleptic promethazine. It exists as a white, crystalline powder … Oxomemazine
