Definition and properties When active pharmaceutical ingredients enter the bloodstream, they often bind to proteins, especially albumin, to a greater or lesser extent. This phenomenon is called protein binding, and it is reversible: drug + protein ⇌ drug-protein complex Protein binding is important, first, because only the free portion distributes to tissues and induces a … Protein Binding
Phenprocoumon is the active ingredient in Marcumar. It is a chemical substance from the group of coumarins. Representatives of this class of substances have anticoagulant properties, so they are important as active pharmaceutical ingredients. They are used as a drug for thrombosis prophylaxis. What is phenprocoumon? Phenprocoumon is the active ingredient in Marcumar. It is … Phenprocoumon: Effects, Uses & Risks
Products Phytomenadione is commercially available as a solution for injection and a solution for oral use (Konakion MM). It has been approved in many countries since 1987. Structure and properties Phytomenadione (C31H46O2, Mr = 450.7 g/mol) is a mixture of -phytomenadione, -phytomenadione, and -epoxyphytomenadione. It exists as a clear, intense yellow, viscous, oily liquid and … Phytomenadione
Products Apixaban has been approved in many countries since 2011 in the form of film-coated tablets (Eliquis). Structure and properties Apixaban (C25H25N5O4, Mr = 460.0 g/mol) was developed starting from razaxaban. It is an oxopiperidine and pyrazole derivative. Effects Apixaban (ATC B01AF02) has antithrombotic properties. It is an oral, direct, potent, selective, and reversible inhibitor … Apixaban
Products Candesartan is commercially available in tablet form (Atacand, Blopress, generics). It is also combined fixed with hydrochlorothiazide (Atacand plus, Blopress plus, generics). Candesartan has been approved in many countries since 1997. In 2020, a fixed combination with amlodipine was also released. Structure and Properties Candesartan (C24H20N6O3, Mr = 440.45 g/mol) is administered in the … Candesartan
Synonyms in a broader sense Phenprocoumon (active ingredient name), coumarins, vitamin K antagonists (inhibitors), anticoagulants, anticoagulants How does Marcumar® work? The drug known under the trade name Marcumar® contains the active ingredient phenprocoumon, which belongs to the main group of coumarins (vitamin K antagonists). The coumarins are molecules that have a suppressive effect on the … Effect of Marcumar®
Side effects Unwanted side effects cannot be ruled out, often accompanying symptoms such as nausea, vomiting, stomach pain, loss of appetite and diarrhoea occur. In some patients, long-term treatment with Marcumar® resulted in constipation, increased hair loss, the appearance of bruising and even undesirable bleeding tendencies. Particularly serious side effects include intracranial bleeding (intracerebral bleeding, … Side effects | Effect of Marcumar®
Products Horse chestnut extracts are available in the form of topical preparations such as gels and ointments, and oral forms such as tablets, dragées, capsules, tinctures, and drops (e.g., Aesculaforce, Phlebostasin, Venostasin). Furthermore, numerous cosmetics and alternative medicine products such as homeopathics and anthroposophics are on the market. In addition to the extracts, the ingredient … Horse Chestnut: Medicinal Uses
Products Dabigatran is commercially available in capsule form (Pradaxa). It has been approved in many countries since 2012. It was first approved in 2008. Structure and properties Dabigatran (C25H25N7O3, Mr = 471.5 g/mol) is present in drugs as mesilate and in the form of the prodrug dabigatran etexilate, which is metabolized in the organism by … Dabigatran
Products Direct oral anticoagulants (abbreviation: DOAKs) are commercially available in the form of film-coated tablets and capsules. By definition, they are oral drugs. Some representatives of the corresponding drug groups are also available as infusion preparations. Rivaroxaban (Xarelto) and dabigatran (Pradaxa) were the first active ingredients to be approved in 2008. The DOAKs were developed … DOAK
Symptoms The possible symptoms and signs of deep vein thrombosis include: Pain or cramping in the legs Swelling (edema), feeling of tension Warmth sensation, overheating Reddish to blue-purple discoloration of the skin Increased visibility of the superficial veins The symptoms are rather nonspecific. Deep vein thrombosis may also be asymptomatic and discovered by chance. A … Deep Vein Thrombosis
Products Direct factor Xa inhibitors are commercially available in the form of film-coated tablets and capsules. In 2008, rivaroxaban (Xarelto) was the first agent in this group to be approved in many countries and in the EU. Today, there are other drugs on the market, which are listed below. Like thrombin inhibitors, these active ingredients … Factor Xa Inhibitors
