The active ingredient saquinavir is a protease inhibitor. The drug is primarily used for the therapy of HIV infections. In this context, the substance saquinavir is mainly used in combination preparations. The drug was approved in 1995. Since a large number of patients quickly developed resistance to the drug, saquinavir was taken off the pharmaceutical … Saquinavir: Effects, Uses & Risks
Products Preparations from garlic bulbs are commercially available in the form of dragées and capsules, among others. Garlic is also available in grocery stores, for example, fresh, dried and as a spice (granules, powder). It has been used as a remedy for thousands of years. Stem plant Garlic L. from the Amaryllis family (Amaryllidaceae) is … Garlic: Medicinal Uses
Background That grapefruit juice can cause drug-drug interactions was discovered by chance in a clinical trial in 1989 and confirmed in an experiment by the same research group in 1991 (Bailey et al, 1989, 1991). This showed that simultaneous ingestion of grapefruit juice with the calcium channel blocker felodipine significantly increases the bioavailability of felodipine. … Interactions with Grapefruit Juice
Products Dabigatran is commercially available in capsule form (Pradaxa). It has been approved in many countries since 2012. It was first approved in 2008. Structure and properties Dabigatran (C25H25N7O3, Mr = 471.5 g/mol) is present in drugs as mesilate and in the form of the prodrug dabigatran etexilate, which is metabolized in the organism by … Dabigatran
Products Most HIV protease inhibitors are commercially available in tablet or capsule form. In addition, a few liquid dosage forms are available for ingestion. Saquinavir (Invirase) was the first to be lanicized in 1995. Structure and properties The first HIV protease inhibitors were modeled on the natural peptide substrate of the HIV protease. The protease … HIV Protease Inhibitor
Products Rifampicin is commercially available as film-coated tablets, coated tablets, capsules, and injectables (Rimactan, generics). In addition to mono, various combination preparations are also available. Rifampicin has been approved in many countries since 1968. This article refers to peroral monotherapy. Structure and properties Rifampicin (C43H58N4O12, Mr = 823 g/mol) exists as a reddish brown to … Rifampicin
Products Saquinavir is commercially available in the form of film-coated tablets (Invirase). It has been approved in many countries since 1996 (United States: 1995). Structure and properties Saquinavir (C38H50N6O5, Mr = 670.8 g/mol) is present in the drug as saquinavir mesilate, a white, weakly hygroscopic powder that is practically insoluble in water. Effects Saquinavir (ATC … Saquinavir
P-glycoprotein P-glycoprotein (P-gp, MDR1) is a primary active efflux transporter with a molecular weight of 170 kDa, belonging to the ABC superfamily and consisting of 1280 amino acids. P-gp is the product of the -gene (formerly: ). P is for , ABC is for . Occurrence P-glycoprotein is found on various tissues of the human … P-Glycoprotein
