Products Aflibercept is marketed as an injectable (Eylea). It was approved in many countries in 2012. Structure and properties Aflibercept (C4318H6788N1164O1304S32) is a recombinant fusion protein consisting of the extracellular portions of human VEGF receptor 1 and 2 coupled to the Fc receptor of human IgG1. Effects Aflibercept (ATC S01LA05) binds the growth factors VEGF-A … Aflibercept
Products Afoxolaner is commercially available in the form of chewable tablets as a veterinary drug for dogs (NexGard). It was approved in many countries in 2015. Structure and properties Afoxolaner (C26H17ClF9N3O3, Mr = 625.9 g/mol) belongs to the isoxazoline group. Effects Afoxolaner (ATCvet QP53BX04) has insecticidal and acaricidal properties. Parasites ingest the active ingredient when … Afoxolan
Products Agalsidase is commercially available as an infusion preparation and has been approved in many countries since 2001 and 2003, respectively: Replagal: agalsidase alfa Fabrazyme: agalsidase beta Structure and properties Agalsidase is a recombinant human α-galactosidase A produced by biotechnological methods. The amino acid sequence is identical to the natural lysosomal enzyme. It is a … Agalsidase
Products There are no drugs containing adrafinil on the market in many countries. Olmifon is no longer marketed. Modafinil can be used as a substitute. Structure and properties Adrafinil (C15H15NO3S, Mr = 289.3 g/mol) is a prodrug that is biotransformed in the body to modafinil. It exists as a white to pinkish-beige crystalline powder that … Adrafinil
Products Epinephrine is commercially available as an injection solution and as an epinephrine auto-injector from various suppliers. The active ingredient is also known as epinephrine, especially in English (in German: Epinephrin). Structure and properties Epinephrine (C9H13NO3, Mr = 183.2 g/mol) exists as a white, crystalline powder with a bitter taste that turns brownish on contact … Adrenaline
Products Epinephrine prefilled syringes (autoinjectors) are commercially available in many countries from various suppliers. The EpiPen has been approved since 1997 and Jext since 2010. Such syringes were originally developed for the army for the administration of antidotes to chemical weapons (e.g., ComboPen in many countries). Structure and properties Epinephrine (C9H13NO3, Mr = 183.2 g/mol) … Epinephrine Prefilled Syringe (Auto-Injector)
Products Aducanumab has been studied in phase III trials and is in the pre-approval phase. The drug is not yet commercially available. The trials were discontinued in March 2019. However, following a re-analysis, the company announced in October 2019 that it expected to file for approval. Apparently, a sufficiently high dose is required for an … Aducanumab
Products Afamelanotide is administered as an implant (Scenesse, Clinuvel). It has had orphan drug status in many countries since 2008. It has not yet been registered with Swissmedic and is not approved as a drug. In the United States, the drug was approved in 2019. Structure and properties Afamelanotide is an analog of α-melanocyte-stimulating hormone … Afamelanotide
Products In 2012, dapagliflozin (Forxiga) was approved in the EU as the first agent in the new group of SGLT2 inhibitors. Several drugs are now on the market worldwide (see below). Structure and properties The SGLT2 inhibitors are derived from phlorizin, a -glucoside and natural substance first isolated from apple tree bark in 1835. Phlorizin … SGLT2 Inhibitor
Products The selective serotonin reuptake inhibitors (SSRIs) are mainly taken in the form of film-coated tablets or capsules. In addition, other dosage forms such as dispersible tablets, melting tablets and drops are available. Zimelidin was the first to be developed in the 1970s and was approved in the early 1980s. Sales had to be discontinued … Selective Serotonin Reuptake Inhibitor
Products is commercially available in many countries in the form of capsules and as powder in sachets (Perenterol) and has been approved since 1990. Perenterol travel has been registered and approved for the treatment of traveler’s diarrhea since 2010. In Europe, the fungus has been used as a probiotic since the 1950s. Structure and properties … Saccharomyces Boulardii
Products The fixed combination of the neprilysin inhibitor sacubitril with valsartan was approved in the United States, the EU, and many countries in 2015 in the form of film-coated tablets (Entresto). The combination is also referred to as LCZ696. Structure and properties Sacubitril (C24H29NO5, Mr = 411.5 g/mol) is an ester prodrug that is hydrolyzed … Sacubitril