Effects Reverse transcriptase inhibitors (ATC J05AF) have antiviral properties against HIV. The effects are due to inhibition of the viral enzyme reverse transcriptase, which transcribes viral RNA into DNA and is important for viral replication. Structure and properties Within the drug group, two distinct classes are distinguished. The so-called nucleoside reverse transcriptase inhibitors, abbreviated NRTIs, … Reverse Transcriptase Inhibitors (HIV)
Products Elvitegravir is commercially available as film-coated tablets in fixed combination with other antiretroviral agents and cobicistat (Stribild, successor: Genvoya). It has been approved in many countries since 2013. Stribild: elvitegravir, cobicistat, emtricitabine, and tenofovirdisoproxil. Genvoya: elvitegravir, cobicistat, emtricitabine and tenofoviralafenamide. Structure and properties Elvitegravir (C23H23ClFNO5, Mr = 447.9 g/mol) is a dihydroquinolone derivative. It … Elvitegravir
Products Cobicistat is commercially available as a monopreparation (Tybost) and as a fixed combination with elvitegravir, emtricitabine, and tenofovirdisoproxil in the form of film-coated tablets (Stribild). It has been approved in many countries since 2013. Other combination products exist with darunavir (Rezolsta) and with atazanavir (Evotaz). Structure and properties Cobicistat (C40H53N7O5S2, Mr = 776.0 g/mol) … Cobicistat
Symptoms The possible symptoms of acute hepatitis include: Mild fever Dark urine Lack of appetite Nausea and vomiting Weakness, fatigue Abdominal pain Jaundice Swelling of the liver and spleen However, hepatitis B can also be asymptomatic. From an acute infection, which lasts about two to four months, chronic hepatitis B can develop in a minority … Hepatitis B Symptoms, Causes and Treatment
Products Doravirin was approved in the US and EU in 2018 and in many countries in 2019 in film-coated tablet form (Pifeltro). It is also combined with lamivudine and tenofovirdisoproxil fixed (Delstrigo). Structure and properties Doravirin (C17H11ClF3N5O3, Mr = 425.8 g/mol) is a pyridinone and triazole derivative that is practically insoluble in water. The drug … Doravirin
Products The drug used to prevent HIV with medication (pre-exposure prophylaxis, PrEP) is available in the form of film-coated tablets (Truvada). PrEP is short for pre-exposure prophylaxis. Structure and properties The following antiviral agents are contained in the drug product: Emtricitabine (200 mg) Tenofovirdisoproxil (245 mg) Effects Both ingredients (ATC J05AR03) have antiviral properties. They … HIV Pre-Exposure Prophylaxis (PrEP)
