Products Lorcaserin is commercially available in the form of film-coated tablets (Belviq). It was approved in the United States on June 27, 2012. It is not currently registered in many countries. Structure and properties Lorcaserin (C 11 H 14 ClN, M r = 195.7 g/mol) is present in drugs as lorcaserin hydrochloride and hemihydrate, a … Lorcaserin
Products Ertugliflozin was approved in the United States in 2017 and in the EU and many countries in 2018 in film-coated tablet form (Steglatro). The agent is also combined fixed with sitagliptin (Steglujan) and with metformin (Segluromet). Structure and properties Ertugliflozin (C22H25ClO7, Mr = 436.9 g/mol) is present in the drug as ertugliflozin-L-pyroglutamic acid, a … Ertugliflozin
Products Pioglitazone is commercially available in tablet form (Actos, generics). It is also available as a fixed-dose combination with metformin (Competact). Pioglitazone has been approved in many countries since 2000. Structure and properties Pioglitazone (C19H20N2O3S, Mr = 356.4 g/mol) belongs to the thiazolidinediones. It is present in drugs as a racemate and as pioglitazone hydrochloride, … Pioglitazone
Structure and properties Sergliflozin (C20H24O7, Mr = 376.4 g/mol) exists as sergliflozinetabonate, an ester prodrug of sergliflozin. Effects Sergliflozin has antidiabetic and antihyperglycemic properties. It is a selective inhibitor of sodium–glucose co-transporter 2 (SGLT2). This transporter is responsible for the reabsorption of glucose at the proximal tubule of the nephron. Inhibition leads to increased excretion … Sergliflozin
Products Semaglutide was approved in the US and EU in 2017 and in many countries in 2018 as a solution for injection (Ozempic). The agent is structurally and pharmacologically related to liraglutide (Victoza), which, unlike semaglutide, is injected once daily (both Novo Nordisk). In 2019, tablets containing semaglutide were approved for the first time in … Semaglutide
Products No finished drug products containing phlorizin are commercially available in many countries. Phlorizin served as a precursor to modern SGLT2 inhibitors, which are antidiabetic drugs administered to treat type 2 diabetes. Structure and properties Phlorizin (C21H24O10, Mr = 436.4 g/mol) is a natural substance from apple tree bark. Effects Unlike modern SGLT2 inhibitors, phlorizin … Phlorizin
Products In 2012, dapagliflozin (Forxiga) was approved in the EU as the first agent in the new group of SGLT2 inhibitors. Several drugs are now on the market worldwide (see below). Structure and properties The SGLT2 inhibitors are derived from phlorizin, a -glucoside and natural substance first isolated from apple tree bark in 1835. Phlorizin … SGLT2 Inhibitor
Stadiums The course of the diabetic foot disease can be divided into different phases. These phases, which are also called the Wagner-Armstrong stages, are one possible form of division. These describe the characteristics of a wound and also consider whether there is an inflammation or a circulatory disorder. The description of the wound ranges from … Stadiums | Diabetic foot
Course of disease The course of the disease of the diabetic foot is different for each patient. Usually an initially insignificant small injury to the foot or a skin defect in the case of pressure sores leads to a rapidly progressing inflammation of the wound. It is therefore important that the patient checks his foot … Course of disease | Diabetic foot
Definition- What is a diabetic foot? The diabetic foot is a term used to describe very specific symptoms and signs of disease that occur in the context of a disease with diabetes. These are the consequences of too high blood sugar levels, which cause damage to the blood vessels and nerves. Characteristic for the diabetic … Diabetic foot
Diagnosis The basis for the development of a diabetic foot is a patient’s disease of diabetes mellitus, usually type 2. In order to make the diagnosis, the diabetes itself must be confirmed by laboratory tests and then the long-term blood sugar value, the HbA1c, must be checked at regular intervals. A detailed examination of the … Diagnosis | Diabetic foot
