Targeted cancer therapy with tyrosine kinase inhibitors

Synonyms Tyrosine kinase inhibitors include : imatinib, sunitinib, midostaurine and many others Introduction Tyrosine kinase inhibitors are also known as tyrosine kinase inhibitors. This is a group of drugs that inhibit the enzyme tyrosine kinase, which is involved in the development, survival and spread of cancer in the body. Tyrosine kinase inhibitors, such as the … Targeted cancer therapy with tyrosine kinase inhibitors

Side effects | Targeted cancer therapy with tyrosine kinase inhibitors

Side effects Tyroin kinase inhibitors are highly potent drugs. Their use can lead to side effects that do not necessarily occur in every patient. In some cases, these can be serious to life-threatening, which is why a doctor should be consulted immediately. In general, treatment with tyrosine kinase inhibitors requires close monitoring of symptoms and … Side effects | Targeted cancer therapy with tyrosine kinase inhibitors

Interaction | Targeted cancer therapy with tyrosine kinase inhibitors

Interaction Tyrosine kinase inhibitors, like many other drugs, are metabolised and broken down by certain enzymes in the liver. Thus, many drugs can influence the effect of tyrosine kinase inhibitors, but tyrosine kinase inhibitors can also influence other drugs. The effect can be enhanced, which is associated with an increased risk of side effects; or … Interaction | Targeted cancer therapy with tyrosine kinase inhibitors

Price | Targeted cancer therapy with tyrosine kinase inhibitors

Price Tyrosine kinase inhibitors are active ingredients from the group of genetically engineered monoclonal antibodies. This newer, targeted treatment of cancer is still very expensive. As a rule, it is a long-term or even life-long therapy to suppress a relapse. Glivec (contains the active ingredient Imatinib) in the therapy of chronic myeloid leukemia costs over … Price | Targeted cancer therapy with tyrosine kinase inhibitors

The tyrosine kinase

What is a tyrosine kinase? Tyrosine kinase is a specific group of enzymes that are functionally assigned to protein kinases in a biochemical sense. Protein kinases reversibly (possibility of back-reaction) transfer phosphate groups to the OH group (hydroxy group) of the amino acid tyrosine. The phosphate group is transferred to the hydroxy group of the … The tyrosine kinase

What is the tyrosine kinase receptor? | The tyrosine kinase

What is the tyrosine kinase receptor? The tyrosine kinase receptor represents a membrane-bound receptor, i.e. a receptor anchored in the cell membrane. Structurally, it is a receptor with a transmembrane complex. This means that the receptor passes through the entire cell membrane and also has an extra- and intracellular side. On the extracellular side, the … What is the tyrosine kinase receptor? | The tyrosine kinase

For which indications are they used? | The tyrosine kinase

For which indications are they used? Tyrosine kinase inhibitors are used for various malignant diseases. Imatinib is used in particular in chronic myeloid leukemia. Further applications are non-small cell lung cancer (NSCLC), breast cancer and colon cancer. Due to the highly selective attack mechanism of tyrosine kinase inhibitors, they are generally better tolerated than conventional … For which indications are they used? | The tyrosine kinase