Products Bextra film-coated tablets are no longer on the market in many countries. Approval was withdrawn in April 2005 because rare severe skin reactions had occurred during treatment (see below). Structure and properties Valdecoxib (C16H14N2O3S, Mr = 314.4 g/mol) is a phenylisoxazole and a benzenesulfonamide derivative. It has a V-shaped structure with which it binds … Valdecoxib
Products COX-2 inhibitors (coxibe) are commercially available in the form of film-coated tablets and capsules. The first representatives from this group to be approved in many countries were celecoxib (Celebrex, USA: 1998) and rofecoxib (Vioxx, off label) in 1999. At that time, they rapidly developed into blockbuster drugs. However, due to adverse effects, several drugs … COX-2 Inhibitor
Products Parecoxib is commercially available in Germany as a powder for solution for injection (Dynastat). It is not approved in many countries. Structure and properties Parecoxib (C19H18N2O4S, Mr = 370.4 g/mol) is a prodrug of valdecoxib that is rapidly metabolized to the active drug in vivo. Effects Parecoxib (ATC M01AH04) is analgesic and anti-inflammatory. Its … Parecoxib