Pharmacodynamics and pharmacokinetics. When we take a tablet, we are usually interested in its immediate effects. The drug is supposed to relieve a headache or reduce symptoms of a cold. At the same time, we may think about the possible side effects it may trigger. The desired and undesired effects that a drug exerts on … ADME
Products Dronedarone is commercially available in the form of film-coated tablets (Multaq). It was approved in 2009, first in the United States, then in Canada, in many countries, and in November throughout the European Union. Structure and properties Dronedarone (C31H44N2O5S, Mr = 556.76 g/mol) is a benzofuran derivative and an analog of the antiarrhythmic drug … Dronedarone
Definition Distribution (distribution) is a pharmacokinetic process that begins immediately after absorption of the drug from the intestine. During this process, the drug enters the bloodstream and travels to organs, body fluids, and tissues. Distribution is necessary for the drug to reach its drug target at a sufficient concentration. For example, an antidepressant must be … Distribution
Definition Plasma concentration is the concentration of a pharmaceutical agent in blood plasma at a given time after administration. Plasma is the liquid portion of blood excluding its cellular components. Concentration is typically expressed in µg/ml. Plasma concentration-time curves If plasma levels are measured several times after administration, a plasma concentration-time curve can be constructed … Plasma Concentration