Troponin for a heart attack
Today, troponin T is the most important laboratory parameter for reliable heart attack diagnosis. The cause of a heart attack is the occlusion of an artery that is normally responsible for supplying the heart muscle. This can be caused by a blood clot, for example.
As a result, the muscle cells that are not supplied with blood perish. If this happens, the cell membrane becomes permeable to larger proteins such as troponin. This is why troponin leaks into the blood during a heart attack, where it can be detected.
However, since a large part of troponin is bound intracellularly to other proteins, this does not happen immediately after the closure of a coronary vessel and the resulting symptoms. Depending on how much of the heart muscle is affected, the first increase does not occur until three to eight hours after the onset of an infarction. Maximum values are often reached up to four days later. Several weeks after a heart attack, the values should have normalised. Diagnosis of heart attack
Troponin in renal insufficiency
In healthy people, the kidney filters the blood. This is no longer the case in people with kidney disease. This insufficient kidney function is called renal insufficiency.
As a result, released troponin accumulates in the blood and, in the long term, the troponin level increases without direct damage to the heart muscle. However, patients with severe kidney damage often have damage or threat to the heart. The causes are manifold and range from the often already high age of the patients, the role of the kidney in blood pressure regulation to the hormonal interaction between heart and kidney.
Clinical studies have shown that high troponin levels in patients with renal failure also indicate a heart at risk. They can therefore be of great prognostic importance. Renal failure
