Laboratory parameters 1st order – obligatory laboratory tests – examination in a special laboratory (protection level 4)!
- Chikungunya virus – pathogen detection from blood:
- PCR, virus culture (in the first 3-5 days).
- IgM, IgG detection from day 8-10.
- Dengue virus:
- DENV RNA – virus detection by PCR (polymerase chain reaction (PCR)* – between day 3-7 of illness.
- Virus cultivation* – between the 3rd – 7th day of illness.
- DENV NS-1 antigen (the NS1 protein is highly conserved within the four serotypes).
- Antibody detection* DENV-specific IgG, IgM – from the 8th day of illness.
- Ebola/Marburg virus – pathogen detection from blood:
- PCR, virus culture in the acute phase.
- IgM, IgG detection from week 4.
- Corpus luteum virus – pathogen detection from blood:
-
- PCR, virus culture in the acute phase.
- IgM, IgG detection only after five to ten days.
- Crimean Congo virus – pathogen detection from blood:
- PCR, virus culture or electron microscopy in the acute phase.
- IgM, IgG detection from the 10th day.
- Lassa virus – pathogen detection from blood:
- PCR, antigen EIA, virus culturing, electron microscopy in the acute phase.
- IgM, IgG detection from the 10th day.
- Rift Valley virus – pathogen detection from blood/tissue.
- PCR, virus culture in the acute phase.
- IgM, IgG detection
- West Nile virus – pathogen detection from serum/liquor.
- Direct virus detection by PCR (only 20-50% of samples PCR positive).
- IgM and IgG at the earliest from the 7th day of illnessCaution: cross-reactive antibodies (TBE, dengue) titer rise (acute – convalescent).
- Small blood count
- Differential blood count
- Inflammatory parameter – CRP (C-reactive protein)
- Fasting glucose (fasting blood sugar)
- Alanine aminotransferase (ALT, GPT), aspartate aminotransferase (AST, GOT), glutamate dehydrogenase (GLDH) and gamma-glutamyl transferase (gamma-GT, GGT), alkaline phosphatase, bilirubin [fever and transaminase elevation:
- Brucellosis
- Dengue fever
- Hepatitides
- Leptospirosis
- Lymphotropic viral infections
- Rickettsial infections
- Syphilis (lues; typical: high alkaline phosphatase, AP).
- Q fever
- Rift Valley Fever
- Viral hemorrhagic fever
- Visceral leishmaniasis (when splenomegaly and pancytopenia (synonym: tricytopenia; reduction of all three cell series in the blood) are also present)]
- Renal parameters – urea, creatinine, possibly cystatin C or creatinine clearance [VHF: renal involvement].
- Coagulation parameters – PTT, Quick
- Blood cultures