What happens when the Cushing’s threshold is crossed? | Cushing’s threshold

What happens when the Cushing’s threshold is crossed?

If the Cushing threshold is exceeded once, no direct consequences are usually to be expected. Since Cushing’s syndrome is a chronic disease, it is unlikely that a single dose overdose will cause symptoms. A long-term exceeding of the Cushing’s threshold becomes problematic.

This greatly increases the probability of developing Cushing’s syndrome with hypercortisolism. Depending on how this manifests itself, a drug therapy to counteract the disease should be considered. So-called adrenostatic drugs can be given to block the synthesis of cortisol in the body. In all cases, however, the cortisone therapy should be reduced as soon as it becomes apparent that the Cushing’s threshold has been exceeded.

Threshold dose of various preparations

Active substance | Cushing’s threshold dose [mg/day] | Preparations Betamethasone | 1 | Celestamine® Dexamethasone | 1.5 | Dexa-CT®, Dexamethasone GALEN® Fluocortolone | 7.5 | Ultralan®-oral Hydrocortisone | 30 | Hydrocortisone Hoechst®, Hydrocutan® methylprednisolone | 6 | Urbason®, M-PredniHEXAL®, Metysolon® prednisolone | 7.5 | Decortin®, Dermosolon, PredniHEXAl® prednisone | 7.5 | Decortin®, PrednisolHEXAL® triamcinolone | 6 | Delphicort®, Volon®

All articles in this series:

  1. Cushing’s threshold
  2. What happens when the Cushing’s threshold is crossed?