Where are they produced?
Preliminary stages of phospholipases are synthesized by the ribosomes of the cells. These are located on the cell organelle endoplasmic reticulum of all cells of the body. When they are active, they release a chain of amino acids, which later form the finished enzyme, into the endoplasmic reticulum.
Here the enzyme matures into the finished enzyme. Some amino acids, for example, which only perform regulatory functions, are already removed. From there, the amino acid chains are transported by special transport vesicles to the cell organelle Golgi apparatus.
Here, the amino acid chains mature again to the finished enzyme. In addition, the enzyme is divided into further transport vesicles that transport it to its destination in the cells. If a phospholipase is not to act in a cell organelle, it is not initially introduced into the endoplasmic reticulum. In this case the amino acid chain is formed by the ribosomes directly in the cytoplasm.
What is a phospholipase inhibitor?
Phospholipase inhibitors are molecules that can reduce the activity of phospholipases. These molecules are not produced by the body, but are synthesized artificially. The aim of the artificial synthesis of phospholipase inhibitors is to make them therapeutically useful in inflammatory reactions.
Since a cleavage product of phospholipases, arachidonic acid, is the starting product for the formation of tissue hormones, inhibition of phospholipase can reduce the effect of tissue hormones. In general, the tissue hormones increase inflammatory reactions. Due to the lower formation of arachidonic acid, less starting material is available for the formation of tissue hormones. The use of phospholipase inhibitors is therefore intended to reduce an inflammatory reaction.